Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 10/20 | 0.38 |
| ▸ | JAK2 | O60674 | 9/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.36 |
| ▸ | ADAM10 | O14672 | 5/20 | 0.34 |
| ▸ | MMP2 | P08253 | 3/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | MMP3 | P08254 | 1/20 | 0.33 |
| ▸ | MMP9 | P14780 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL388446 | 1.00 | JAK1 (0.38) | JAK1JAK2GPR119ADAM10MMP2 | |
| SCHEMBL389720 | 1.00 | JAK1 (0.38) | JAK1JAK2GPR119ADAM10MMP2 | |
| SCHEMBL387151 | 0.95 | JAK1 (0.36) | JAK1JAK2GPR119HRH3 | |
| SCHEMBL389751 | 0.95 | HRH3 (0.34) | JAK1JAK2GPR119HRH3 | |
| SCHEMBL390073 | 0.91 | HRH3 (0.36) | GPR119HRH3 | |
| SCHEMBL389666 | 0.90 | JAK2 (0.36) | JAK1JAK2GPR119 | |
| SCHEMBL391229 | 0.89 | HRH3 (0.35) | HRH3 | |
| SCHEMBL386757 | 0.88 | HRH3 (0.34) | HRH3 | |
| SCHEMBL391834 | 0.87 | HRH3 (0.34) | HRH3 | |
| SCHEMBL388767 | 0.86 | KCNH2 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8101626-B2 | GPR119 receptor agonists in methods of increasing bone mass and of treating osteoporosis and other conditions characterized by low bone mass, and combination therapy relating thereto | ARENA PHARMACEUTICALS, INC. (US) | 2012-01-24 | — | — | US | disclosed |
| EP-2004157-B1 | USE OF GPR119 RECEPTOR AGONISTS FOR INCREASING BONE MASS AND FOR TREATING OSTEOPOROSIS, AS WELL AS COMBINATION THERAPY RELATING THERETO | ARENA PHARM INC (US) | 2011-01-12 | — | — | EP | disclosed |