Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 19/20 | 0.49 |
| ▸ | MAP2K2 | P36507 | 4/20 | 0.49 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.49 |
| ▸ | IARS2 | Q9NSE4 | 1/20 | 0.49 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5479761 | 0.86 | MAP2K1 (0.47) | MAP2K1MAP2K2PRKCZIARS2 | |
| SCHEMBL5485434 | 0.84 | MAP2K1 (0.45) | MAP2K1MAP2K2PRKCZIARS2 | |
| SCHEMBL5484776 | 0.83 | MAP2K1 (0.50) | MAP2K1MAP2K2PRKCZIARS2 | |
| SCHEMBL3887238 | 0.79 | MAP2K1 (0.47) | MAP2K1MAP2K2PRKCZIARS2IDO1 | |
| SCHEMBL5475038 | 0.78 | MAP2K1 (0.43) | MAP2K1MAP2K2PRKCZIARS2 | |
| SCHEMBL1488238 | 0.78 | MAP2K1 (0.64) | MAP2K1MAP2K2PRKCZIARS2IDO1 | |
| SCHEMBL29413415 | 0.78 | MAP2K1 (0.64) | MAP2K1MAP2K2PRKCZIARS2IDO1 | |
| SCHEMBL29682048 | 0.78 | MAP2K1 (0.64) | MAP2K1MAP2K2PRKCZIARS2IDO1 | |
| SCHEMBL5485309 | 0.77 | MAP2K1 (0.45) | MAP2K1MAP2K2PRKCZIARS2IDO1 | |
| SCHEMBL24539455 | 0.75 | MAP2K1 (0.56) | MAP2K1MAP2K2PRKCZIARS2IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2013180-A1 | NOVEL HETEROARYL-SUBSTITUTED ARYLAMINOPYRIDINE DERIVATIVES AS MEK INHIBITORS | Laboratoires Serono SA (CH) | 2009-01-14 | — | — | EP | disclosed |
| WO-2007123936-A1 | NOVEL HETEROARYL-SUBSTITUTED ARYLAMINOPYRIDINE DERIVATIVES AS MEK INHIBITORS | LABORATOIRES SERONO SA (CH) | 2007-11-01 | — | — | WO | disclosed |