Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GDA | Q9Y2T3 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | XDH | P47989 | 1/20 | 0.32 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.32 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL94902 | 0.75 | — | — | |
| SCHEMBL101340 | 0.75 | — | — | |
| Hydrochloric Acid SCHEMBL1776088 | 0.74 | GDA (0.96) | GDALMNAKDM4ETSHRSMN1; SMN2 | |
| SCHEMBL15832982 | 0.73 | GAA (0.39) | GDALMNAKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL9708864 | 0.73 | GDA (0.60) | GDALMNAKDM4ETSHRSMN1; SMN2 | |
| SCHEMBL2202786 | 0.73 | GDA (0.60) | GDAKDM4ESMN1; SMN2ALDH1A1GAA | |
| SCHEMBL3864458 | 0.69 | — | — | |
| SCHEMBL21286900 | 0.69 | GDA (0.60) | GDALMNAKDM4ETSHRSMN1; SMN2 | |
| Phosphoric Acid SCHEMBL2779124 | 0.69 | GDA (0.85) | GDALMNAKDM4ETSHRSMN1; SMN2 | |
| SCHEMBL2491314 | 0.69 | KDM4E (0.64) | GDALMNAKDM4ESMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140212981-A1 | METHODS AND SYSTEMS FOR DETERMINING THE AMOUNT OF THIOPURINE METABOLITES IN A SAMPLE | LABORATORY CORPORATION OF AMERICA HOLDINGS (US) | 2014-07-31 | — | — | US | claimed |
| WO-2014100405-A1 | METHODS AND SYSTEMS FOR DETERMINING THE AMOUNT OF THIOPURINE METABOLITES IN A SAMPLE | LABORATORY CORPORATION OF AMERICA HOLDINGS (US) | 2014-06-26 | — | — | WO | claimed |
| WO-2016027106-A1 | CELL ASSAY | UNIVERSITY OF NEWCASTLE UPON TYNE (GB) | 2016-02-25 | — | — | WO | disclosed |
| US-20140212981-A1 | METHODS AND SYSTEMS FOR DETERMINING THE AMOUNT OF THIOPURINE METABOLITES IN A SAMPLE | LABORATORY CORPORATION OF AMERICA HOLDINGS (US) | 2014-07-31 | — | — | US | disclosed |
| WO-2014100405-A1 | METHODS AND SYSTEMS FOR DETERMINING THE AMOUNT OF THIOPURINE METABOLITES IN A SAMPLE | LABORATORY CORPORATION OF AMERICA HOLDINGS (US) | 2014-06-26 | — | — | WO | disclosed |
| EP-1825254-A4 | METHOD FOR OPTIMIZING THIOPURINE EFFICACY AND TOXICITY USING MASS SPECTROMETRY | PROMETHEUS LAB INC (US) | 2009-01-14 | — | — | EP | disclosed |
| EP-1825254-A2 | METHOD FOR OPTIMIZING THIOPURINE EFFICACY AND TOXICITY USING MASS SPECTROMETRY | Prometheus Laboratories, Inc. (US) | 2007-08-29 | — | — | EP | disclosed |
| US-20060216726-A1 | Method for optimizing thiopurine efficacy and toxicity using mass spectrometry | PROMETHEUS LABORATORIES INC. (US) | 2006-09-28 | — | — | US | disclosed |
| WO-2006055527-A2 | METHOD FOR OPTIMIZING THIOPURINE EFFICACY AND TOXICITY USING MASS SPECTROMETRY | PROMETHEUS LABORATORIES INC. (US) | 2006-05-26 | — | — | WO | disclosed |