Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 9/20 | 0.36 |
| ▸ | SRC | P12931 | 5/20 | 0.34 |
| ▸ | KDR | P35968 | 3/20 | 0.33 |
| ▸ | ABL1 | P00519 | 2/20 | 0.33 |
| ▸ | FLT1 | P17948 | 2/20 | 0.33 |
| ▸ | SYK | P43405 | 2/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.31 |
| ▸ | RAD52 | P43351 | 1/20 | 0.30 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3884236 | 0.89 | EGFR (0.38) | EGFRSRCKDRABL1FLT1 | |
| SCHEMBL3880451 | 0.88 | EGFR (0.39) | EGFRSRCKDRABL1FLT1 | |
| SCHEMBL3882523 | 0.88 | EGFR (0.39) | EGFRSRCKDRABL1FLT1 | |
| SCHEMBL3880080 | 0.87 | EGFR (0.38) | EGFRSRCKDRABL1FLT1 | |
| SCHEMBL3881229 | 0.83 | EGFR (0.38) | EGFRSRCKDRABL1FLT1 | |
| SCHEMBL3884015 | 0.83 | EGFR (0.40) | EGFRSRCKDRABL1FLT1 | |
| SCHEMBL3883318 | 0.82 | EGFR (0.39) | EGFRSRCKDRABL1FLT1 | |
| SCHEMBL3880153 | 0.81 | EGFR (0.39) | EGFRSRCKDRABL1FLT1 | |
| SCHEMBL3884489 | 0.81 | EGFR (0.34) | EGFRSRCKDRABL1FLT1 | |
| SCHEMBL3948070 | 0.79 | EGFR (0.35) | EGFRSRCKDRABL1FLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1771443-B1 | QUINOLINE THIAZOLINONES WITH CDK-1 ANTIPROLIFERATIVE ACTIVITY | HOFFMANN LA ROCHE (CH) | 2009-01-07 | — | — | EP | claimed |