Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 10/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.33 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.33 |
| ▸ | GSK3A | P49840 | 1/20 | 0.33 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.33 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.33 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | MET | P08581 | 2/20 | 0.31 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.31 |
| ▸ | ASAH1 | Q13510 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL388627 | 0.87 | CHEK1 (0.34) | KMOMAPTCHEK1AURKADAPK3 | |
| SCHEMBL3515408 | 0.77 | CHEK1 (0.42) | KMOMAPTCHEK1AURKADAPK3 | |
| SCHEMBL3710758 | 0.75 | ERN1 (0.34) | KMOMAPTCHEK1AURKADAPK3 | |
| SCHEMBL29804021 | 0.68 | KMT2A (0.44) | KMOMAPTCHEK1AURKADAPK3 | |
| SCHEMBL18168026 | 0.68 | CHEK1 (0.45) | KMOMAPTCHEK1AURKADAPK3 | |
| SCHEMBL20791823 | 0.68 | SLC22A12 (0.38) | KMOMAPTCHEK1AURKADAPK3 | |
| SCHEMBL29241416 | 0.68 | CHEK1 (0.49) | MAPTCHEK1AURKADAPK3CSNK1A1 | |
| SCHEMBL12058336 | 0.67 | EGFR (0.41) | CHEK1AURKADAPK3CSNK1A1GSK3A | |
| SCHEMBL17847964 | 0.67 | CCR9 (0.39) | KMOMAPTCHEK1AURKADAPK3 | |
| SCHEMBL31691580 | 0.65 | CHEK1 (0.49) | KMOMAPTCHEK1AURKADAPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2408761-A1 | SUBSTITUTED INDOLE DERIVATIVES AND METHODS OF USE THEREOF | Schering Corporation (US) | 2012-01-25 | — | — | EP | disclosed |
| CN-102159579-A | Tricyclic indole derivatives and methods of use thereof | SCHERING CORP | 2011-08-17 | — | — | CN | disclosed |
| CN-101842376-A | Tetracyclic indole derivatives and being used for the treatment of or prophylaxis of viral infections | SCHERING CORP | 2010-09-22 | — | — | CN | disclosed |
| CN-101842374-A | 2, 3-substituted azaindole derivatives for the treatment of viral infections | SCHERING CORP | 2010-09-22 | — | — | CN | disclosed |
| WO-2009032124-A1 | SUBSTITUTED INDOLE DERIVATIVES AND METHODS OF USE THEREOF | SCHERING CORPORATION (US) | 2009-03-12 | — | — | WO | disclosed |