Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 6/20 | 0.56 |
| ▸ | PDE3A | Q14432 | 5/20 | 0.56 |
| ▸ | DYRK1A | Q13627 | 6/20 | 0.53 |
| ▸ | MEN1 | O00255 | 4/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | DYRK2 | Q92630 | 3/20 | 0.53 |
| ▸ | PIM1 | P11309 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.53 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 3/20 | 0.50 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.50 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.48 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.48 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.48 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14452720 | 1.00 | PDE4B (0.56) | PDE4BPDE3ADYRK1AMEN1KMT2A | |
| SCHEMBL3887446 | 1.00 | PDE4B (0.56) | PDE4BPDE3ADYRK1AMEN1KMT2A | |
| SCHEMBL13955932 | 0.83 | PDE4B (0.56) | PDE4BPDE3ADYRK1AMEN1KMT2A | |
| SCHEMBL3885317 | 0.81 | NAT1 (0.52) | PDE4BPDE3ADYRK1AMEN1KMT2A | |
| SCHEMBL3885314 | 0.81 | NAT1 (0.52) | PDE4BPDE3ADYRK1AMEN1KMT2A | |
| SCHEMBL13956118 | 0.81 | NAT1 (0.52) | PDE4BPDE3ADYRK1AMEN1KMT2A | |
| SCHEMBL3886628 | 0.80 | KMT2A (0.54) | DYRK1AMEN1KMT2APIM1ALDH1A1 | |
| SCHEMBL13955946 | 0.79 | MYC (0.47) | DYRK1AMEN1KMT2APIM1ALDH1A1 | |
| SCHEMBL3883359 | 0.79 | KMT2A (0.41) | DYRK1AMEN1KMT2APIM1ALDH1A1 | |
| SCHEMBL3883361 | 0.79 | KMT2A (0.41) | DYRK1AMEN1KMT2APIM1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1771443-B1 | QUINOLINE THIAZOLINONES WITH CDK-1 ANTIPROLIFERATIVE ACTIVITY | HOFFMANN LA ROCHE (CH) | 2009-01-07 | — | — | EP | disclosed |
| US-7250515-B2 | Thiazolinone 3,4-disubstituted quinolines | HOFFMAN-LA ROCHE INC. (US) | 2007-07-31 | — | — | US | disclosed |
| EP-1771443-A1 | QUINOLINE THIAZOLINONES WITH CDK1 ANTIPROLIFERATIVE ACTIVITY | F.HOFFMANN-LA ROCHE AG (CH) | 2007-04-11 | — | — | EP | disclosed |
| WO-2006002828-A1 | QUINOLINE THIAZOLINONES WITH CDK1 ANTIPROLIFERATIVE ACTIVITY | F. HOFFMANN-LA ROCHE AG (CH) | 2006-01-12 | — | — | WO | disclosed |
| US-20060004046-A1 | Thiazolinone 3,4-disubstituted quinolines | CHEN LI | 2006-01-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060004046-A1 | Thiazolinone 3,4-disubstituted quinolines | CDK1, CDK17, CDK14 | PDE4B 2464/4885PDE3A 3579/4885DYRK1A 537/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.