Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Isoleucine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC1A3 | P43003 | 4/20 | 0.37 |
| ▸ | SLC1A2 | P43004 | 4/20 | 0.37 |
| ▸ | SLC1A1 | P43005 | 3/20 | 0.37 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.36 |
| ▸ | GRIK1 | P39086 | 9/20 | 0.34 |
| ▸ | GRIA4 | P48058 | 3/20 | 0.34 |
| ▸ | GRIK3 | Q13003 | 3/20 | 0.34 |
| ▸ | GRIK5 | Q16478 | 3/20 | 0.34 |
| ▸ | GRIK2 | Q13002 | 5/20 | 0.33 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.33 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.32 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | PDCD1LG2 | Q9BQ51 | 1/20 | 0.32 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Isoleucine SCHEMBL27709387 | 1.00 | SLC1A3 (0.37) | SLC1A3SLC1A2SLC1A1SLC7A5GRIK1 | |
| Isoleucine SCHEMBL384266 | 0.96 | SLC7A5 (0.40) | SLC1A3SLC1A2SLC1A1SLC7A5GRIK1 | |
| Isoleucine SCHEMBL19813749 | 0.96 | SLC7A5 (0.40) | SLC1A3SLC1A2SLC1A1SLC7A5GRIK1 | |
| Isoleucine SCHEMBL28445029 | 0.94 | SLC1A3 (0.41) | SLC1A3SLC1A2SLC1A1SLC7A5GRIK1 | |
| Isoleucine SCHEMBL1965718 | 0.94 | SLC1A3 (0.41) | SLC1A3SLC1A2SLC1A1SLC7A5GRIK1 | |
| Isoleucine SCHEMBL610595 | 0.94 | SLC1A3 (0.41) | SLC1A3SLC1A2SLC1A1SLC7A5GRIK1 | |
| Isoleucine SCHEMBL8579283 | 0.94 | SLC1A3 (0.41) | SLC1A3SLC1A2SLC1A1SLC7A5GRIK1 | |
| Isoleucine SCHEMBL4617349 | 0.94 | SLC1A3 (0.41) | SLC1A3SLC1A2SLC1A1SLC7A5GRIK1 | |
| Isoleucine SCHEMBL4611263 | 0.94 | SLC7A5 (0.38) | SLC1A3SLC1A2SLC1A1SLC7A5GRIK1 | |
| Asparagine SCHEMBL22382261 | 0.91 | SLC7A5 (0.42) | SLC1A3SLC1A2SLC1A1SLC7A5GRIK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8101716-B2 | Human interferon-beta mutein | Shin, Young Kee (KR) | 2012-01-24 | — | — | US | disclosed |
| EP-1809661-B1 | HUMAN INTERFERON-BETA MUTEIN | SHIN YOUNG KEE (KR) | 2011-05-18 | — | — | EP | disclosed |
| US-20100003721-A1 | HUMAN INTERFERON-BETA MUTEIN | Shin, Young Kee (KR) | 2010-01-07 | — | — | US | disclosed |
| EP-1809661-A4 | HUMAN INTERFERON-BETA MUTEIN | SHIN YOUNG KEE (KR) | 2008-02-06 | — | — | EP | disclosed |
| EP-1809661-A1 | HUMAN INTERFERON-BETA MUTEIN | Shin, Young Kee (KR) | 2007-07-25 | — | — | EP | disclosed |
| WO-2006049423-A1 | HUMAN INTERFERON-BETA MUTEIN | SAMSUNG FINE CHEMICALS CO LTD (KR) | 2006-05-11 | — | — | WO | disclosed |