Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GALR2 | O43603 | 4/20 | 0.46 |
| ▸ | GALR1 | P47211 | 4/20 | 0.46 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.42 |
| ▸ | GRM5 | P41594 | 4/20 | 0.40 |
| ▸ | GBA1 | P04062 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3878564 | 0.99 | GALR2 (0.44) | GALR2GALR1TRPV1GRM5GBA1 | |
| SCHEMBL3876785 | 0.91 | GALR2 (0.43) | GALR2GALR1TRPV1GBA1KDM4E | |
| SCHEMBL3884876 | 0.90 | MALT1 (0.44) | GALR2GALR1TRPV1GBA1KMT2A | |
| SCHEMBL14613984 | 0.89 | GALR2 (0.46) | GALR2GALR1GRM5GBA1KMT2A | |
| SCHEMBL3879767 | 0.89 | TRPV1 (0.49) | GALR2GALR1TRPV1GRM5HSD11B1 | |
| SCHEMBL3881042 | 0.88 | TRPV1 (0.50) | GALR2GALR1TRPV1GRM5HSD11B1 | |
| SCHEMBL3877121 | 0.88 | TRPV1 (0.42) | TRPV1GRM5 | |
| SCHEMBL3887140 | 0.88 | TRPV1 (0.50) | GALR2GALR1TRPV1GRM5HSD11B1 | |
| SCHEMBL3888381 | 0.87 | GALR2 (0.61) | GALR2GALR1TRPV1GBA1 | |
| SCHEMBL3879062 | 0.87 | TRPV1 (0.43) | TRPV1GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7566712-B2 | Biaryl piperazinyl-pyridine analogues | NEUROGEN CORPORATION (US) | 2009-07-28 | — | — | US | disclosed |
| US-7566712-B2 | Biaryl piperazinyl-pyridine analogues | NEUROGEN CORPORATION (US) | 2009-07-28 | — | — | US | disclosed |
| US-7566712-B2 | Biaryl piperazinyl-pyridine analogues | NEUROGEN CORPORATION (US) | 2009-07-28 | — | — | US | disclosed |