Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 2/20 | 0.68 |
| ▸ | GOPC | Q9HD26 | 2/20 | 0.68 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.68 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.68 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.63 |
| ▸ | KCNA5 | P22460 | 6/20 | 0.53 |
| ▸ | KCNN4 | O15554 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.49 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.45 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3887188 | 0.93 | CFTR (0.62) | CFTRGOPCSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL17069272 | 0.87 | CFTR (0.59) | CFTRGOPCSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL10442149 | 0.87 | CFTR (0.59) | CFTRGOPCSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL30326956 | 0.84 | SMN1; SMN2 (0.61) | CFTRGOPCSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL27176402 | 0.84 | SMN1; SMN2 (0.61) | CFTRGOPCSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL1378412 | 0.83 | KCNA5 (0.56) | CFTRGOPCSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL3888426 | 0.83 | KCNA5 (0.56) | CFTRGOPCSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL1381367 | 0.82 | CFTR (0.53) | CFTRGOPCSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL6476580 | 0.81 | SLC6A2 (1.00) | CFTRGOPCSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL1380208 | 0.80 | KCNA5 (0.51) | CFTRGOPCSLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7569589-B2 | Potassium channel inhibitors | MERCK & CO., INC. (US) | 2009-08-04 | — | — | US | disclosed |
| US-7569589-B2 | Potassium channel inhibitors | MERCK & CO., INC. (US) | 2009-08-04 | — | — | US | disclosed |
| US-7569589-B2 | Potassium channel inhibitors | MERCK & CO., INC. (US) | 2009-08-04 | — | — | US | disclosed |
| US-20060030595-A1 | (R)-N-{6-[1-(4-fluorophenyl)-2,2-dipyridin-3-ylethyl]pyridin-2-yl}methanesulfonamide; cardiac arrhythmias | MERCK SHARP & DOHME LLC | 2006-02-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060030595-A1 | (R)-N-{6-[1-(4-fluorophenyl)-2,2-dipyridin-3-ylethyl]pyridin-2-yl}methanesulfonamide; cardiac arrhythmias | KCNN2, KCNJ2, KCNH2 | CFTR 983/4885GOPC 2299/4885SLC6A2 2093/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.