Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.40 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL1647594 | 0.86 | KMT2A (0.51) | KMT2ASMN1; SMN2LMNATHRBCYP2C19 | |
| Bromide SCHEMBL1647384 | 0.82 | KMT2A (0.55) | KMT2ASMN1; SMN2LMNATHRBCYP2C19 | |
| SCHEMBL2231665 | 0.80 | KMT2A (0.52) | KMT2ASMN1; SMN2LMNATHRBCYP2C19 | |
| Bromide SCHEMBL3890738 | 0.79 | KMT2A (0.57) | KMT2ASMN1; SMN2LMNATHRBPOLB | |
| Bromide SCHEMBL3894863 | 0.78 | KMT2A (0.53) | KMT2ASMN1; SMN2LMNATHRBPOLB | |
| Bromide SCHEMBL3890517 | 0.74 | KMT2A (0.59) | KMT2ATHRBPOLBMEN1HTT | |
| Bromide SCHEMBL3897209 | 0.74 | KMT2A (0.63) | KMT2ASMN1; SMN2LMNATHRBPOLB | |
| Bromide SCHEMBL3885379 | 0.73 | KMT2A (0.66) | KMT2ASMN1; SMN2LMNATHRBCYP2C19 | |
| Bromide SCHEMBL1645919 | 0.72 | KMT2A (0.73) | KMT2ASMN1; SMN2LMNATHRBPOLB | |
| SCHEMBL8237046 | 0.72 | SMN1; SMN2 (0.61) | KMT2ASMN1; SMN2LMNACYP2C19CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888063-B1 | ANTIFUNGAL AGENTS | F2G LTD (GB) | 2009-01-14 | — | — | EP | disclosed |