Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 3/20 | 0.73 |
| ▸ | SCN9A | Q15858 | 8/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.53 |
| ▸ | SCN5A | Q14524 | 6/20 | 0.53 |
| ▸ | PRMT5 | O14744 | 5/20 | 0.51 |
| ▸ | WDR77 | Q9BQA1 | 5/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3756047 | 0.96 | KCNA5 (0.73) | KCNA5SCN9AKCNH2SCN5APRMT5 | |
| SCHEMBL3744033 | 0.93 | KCNA5 (0.80) | KCNA5SCN9AKCNH2SCN5APRMT5 | |
| SCHEMBL3750669 | 0.90 | KCNA5 (0.86) | KCNA5SCN9AKCNH2SCN5APRMT5 | |
| SCHEMBL3750902 | 0.89 | KCNA5 (0.73) | KCNA5SCN9AKCNH2SCN5APRMT5 | |
| SCHEMBL3758069 | 0.87 | KCNA5 (0.70) | KCNA5SCN9AKCNH2SCN5APRMT5 | |
| SCHEMBL3758908 | 0.86 | KCNA5 (0.69) | KCNA5SCN9AKCNH2SCN5APRMT5 | |
| SCHEMBL3755355 | 0.85 | KCNA5 (0.52) | KCNA5SCN9AKCNH2SCN5APRMT5 | |
| SCHEMBL3755943 | 0.85 | KCNA5 (1.00) | KCNA5SCN9AKCNH2SCN5ATDP1 | |
| SCHEMBL3744491 | 0.82 | KCNA5 (0.68) | KCNA5SCN9AKCNH2SCN5APRMT5 | |
| SCHEMBL3752643 | 0.82 | KCNA5 (0.81) | KCNA5SCN9AKCNH2SCN5APRMT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009145718-A1 | ISOINDOLINE DERIVATIVES COMPRISING AN ADDITIONAL HETEROCYCLIC GROUP AND THEIR USE IN THE TREATMENT OF PAIN DISORDERS | ASTRAZENECA AB (SE) | 2009-12-03 | — | — | WO | disclosed |