⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3893345 | 0.92 | — | — | |
| SCHEMBL3895104 | 0.89 | SLC6A2 (0.67) | — | |
| SCHEMBL3893698 | 0.87 | — | — | |
| SCHEMBL3891748 | 0.87 | SLC6A2 (0.85) | — | |
| SCHEMBL3892139 | 0.87 | SLC6A2 (0.64) | — | |
| SCHEMBL3894029 | 0.86 | — | — | |
| SCHEMBL3893101 | 0.86 | SLC6A2 (0.64) | — | |
| SCHEMBL12156358 | 0.85 | SLC6A2 (0.63) | — | |
| SCHEMBL3891744 | 0.85 | SLC6A2 (0.63) | — | |
| SCHEMBL3895589 | 0.85 | SLC6A2 (0.63) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1002794-B1 | 4-¬(Aryl)(aryloxy)methyl piperidine derivatives and their use as serotonin and/or noradrenaline reuptake inhibitors | FAES FABRICA ESPANOLA DE PRODU (ES) | 2009-02-04 | — | — | EP | claimed |
| US-20230117324-A1 | OXAZINE MONOACYLGLYCEROL LIPASE (MAGL) INHIBITORS | HOFFMANN-LA ROCHE INC. (US) | 2023-04-20 | — | — | US | disclosed |
| US-20130131079-A1 | FLUFENOXINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF AMYLOID PATHOLOGIES | FAES FARMA, S.A. (ES) | 2013-05-23 | — | — | US | disclosed |
| US-20130131079-A1 | FLUFENOXINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF AMYLOID PATHOLOGIES | FAES FARMA, S.A. (ES) | 2013-05-23 | — | — | US | disclosed |
| WO-2011147780-A1 | FLUFENOXINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF AMILOYD PATHOLOGIES | FAES FARMA, S.A. (ES) | 2011-12-01 | — | — | WO | disclosed |
| EP-2390248-A1 | Flufenoxine derivatives for the treatment and prevention of amiloyd pathologies | FAES FARMA, S.A. (ES) | 2011-11-30 | — | — | EP | disclosed |
| EP-1002794-B1 | 4-¬(Aryl)(aryloxy)methyl piperidine derivatives and their use as serotonin and/or noradrenaline reuptake inhibitors | FAES FABRICA ESPANOLA DE PRODU (ES) | 2009-02-04 | — | — | EP | disclosed |