Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.62 |
| ▸ | DGKA | P23743 | 1/20 | 0.52 |
| ▸ | PAM | P19021 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.48 |
| ▸ | PPARG | P37231 | 7/20 | 0.48 |
| ▸ | PPARD | Q03181 | 7/20 | 0.48 |
| ▸ | PPARA | Q07869 | 7/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.48 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | TLR2 | O60603 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | FABP4 | P15090 | 2/20 | 0.48 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.48 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | ESR1 | P03372 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | PDE4A | P27815 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7762583 | 0.96 | TSHR (0.67) | TSHRDGKAPAMLMNAGPR84 | |
| SCHEMBL14344225 | 0.96 | TSHR (0.67) | TSHRDGKAPAMLMNAGPR84 | |
| SCHEMBL20476 | 0.96 | TSHR (0.67) | TSHRDGKAPAMLMNAGPR84 | |
| SCHEMBL7540354 | 0.96 | TSHR (0.67) | TSHRDGKAPAMLMNAGPR84 | |
| SCHEMBL18055 | 0.96 | TSHR (0.67) | TSHRDGKAPAMLMNAGPR84 | |
| SCHEMBL25420469 | 0.96 | TSHR (0.67) | TSHRDGKAPAMLMNAGPR84 | |
| SCHEMBL680310 | 0.96 | TSHR (0.67) | TSHRDGKAPAMLMNAGPR84 | |
| SCHEMBL953501 | 0.96 | TSHR (0.67) | TSHRDGKAPAMLMNAGPR84 | |
| SCHEMBL10543145 | 0.96 | TSHR (0.67) | TSHRDGKAPAMLMNAGPR84 | |
| SCHEMBL346985 | 0.96 | TSHR (0.67) | TSHRDGKAPAMLMNAGPR84 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1477527-B1 | AROMATIC POLYCARBONATE RESINS FOR OPTICAL DISK SUBSTRATES | IDEMITSU KOSAN CO (JP) | 2009-01-14 | — | — | EP | disclosed |
| US-7122614-B2 | Aromatic polycarbonate resins for optical disk substrates | IDEMITSU KOSAN CO., LTD. (JP) | 2006-10-17 | — | — | US | disclosed |
| US-20050165204-A1 | Aromatic polycarbonate resins for optical disk substrates | IDEMITSU PETROCHEMICAL CO., LTD (JP) | 2005-07-28 | — | — | US | disclosed |
| EP-1477527-A1 | AROMATIC POLYCARBONATE RESINS FOR OPTICAL DISK SUBSTRATES | IDEMITSU PETROCHEMICAL CO., LTD. (JP) | 2004-11-17 | — | — | EP | disclosed |