Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B2 | P37059 | 1/20 | 0.55 |
| ▸ | CA12 | O43570 | 3/20 | 0.49 |
| ▸ | CA1 | P00915 | 3/20 | 0.49 |
| ▸ | CA2 | P00918 | 3/20 | 0.49 |
| ▸ | CA7 | P43166 | 3/20 | 0.49 |
| ▸ | CA9 | Q16790 | 3/20 | 0.49 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.49 |
| ▸ | ESR1 | P03372 | 2/20 | 0.45 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2645488 | 0.89 | HSD17B2 (0.51) | HSD17B2CA12CA1CA2CA7 | |
| SCHEMBL3654864 | 0.88 | HSD17B2 (0.56) | HSD17B2CA12CA1CA2CA7 | |
| SCHEMBL13715259 | 0.87 | HSD17B2 (0.50) | HSD17B2CA12CA1CA2CA7 | |
| SCHEMBL22324058 | 0.87 | EGFR (0.50) | CA12CA1CA2CA7CA9 | |
| SCHEMBL3480463 | 0.87 | HSD17B2 (0.59) | HSD17B2CA12CA1CA2CA7 | |
| SCHEMBL27101323 | 0.86 | HSD17B2 (0.52) | HSD17B2CA12CA1CA2CA7 | |
| SCHEMBL1630042 | 0.85 | HSD17B2 (0.57) | HSD17B2CA12CA1CA2CA7 | |
| SCHEMBL18425105 | 0.84 | HSD17B2 (0.64) | HSD17B2CA12CA1CA2CA7 | |
| SCHEMBL19230528 | 0.83 | HSD17B2 (0.52) | HSD17B2CA12CA1CA2CA7 | |
| SCHEMBL23304712 | 0.83 | TSHR (0.56) | HSD17B2CA12CA1CA2CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7572790-B2 | Biphenyl carboxylic amide p38 kinase inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 2009-08-11 | — | — | US | disclosed |
| US-7572790-B2 | Biphenyl carboxylic amide p38 kinase inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 2009-08-11 | — | — | US | disclosed |
| US-7572790-B2 | Biphenyl carboxylic amide p38 kinase inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 2009-08-11 | — | — | US | disclosed |
| US-20070129354-A1 | Biphenyl carboxylic amide p38 kinase inhibitors | GLAXOSMITHKLINE LLC | 2007-06-07 | — | — | US | disclosed |
| US-20070129354-A1 | Biphenyl carboxylic amide p38 kinase inhibitors | GLAXOSMITHKLINE LLC | 2007-06-07 | — | — | US | disclosed |
| US-20070129354-A1 | Biphenyl carboxylic amide p38 kinase inhibitors | GLAXOSMITHKLINE LLC | 2007-06-07 | — | — | US | disclosed |
| EP-1608616-A1 | BIPHENYL CARBOXYLIC AMIDE P38 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-12-28 | — | — | EP | disclosed |
| WO-2004089874-A1 | BIPHENYL CARBOXYLIC AMIDE P38 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-10-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070129354-A1 | Biphenyl carboxylic amide p38 kinase inhibitors | MAPK1, MAPKAPK2, MAPK7 | HSD17B2 1001/4885CA12 4619/4885CA1 4206/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.