Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA3 | P22001 | 18/20 | 0.69 |
| ▸ | MEN1 | O00255 | 2/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3908721 | 0.89 | KCNA3 (0.76) | KCNA3MEN1KMT2AALDH1A1 | |
| SCHEMBL3900639 | 0.88 | KCNA3 (0.74) | KCNA3MEN1KMT2AALDH1A1 | |
| SCHEMBL3900558 | 0.87 | KCNA3 (0.68) | KCNA3MEN1KMT2AALDH1A1 | |
| SCHEMBL13939545 | 0.84 | KCNA3 (0.74) | KCNA3MEN1KMT2AALDH1A1 | |
| SCHEMBL3905028 | 0.83 | KCNA3 (0.68) | KCNA3MEN1KMT2AALDH1A1 | |
| SCHEMBL1946359 | 0.82 | KCNA3 (1.00) | KCNA3MEN1KMT2AALDH1A1 | |
| SCHEMBL31685209 | 0.82 | KCNA3 (1.00) | KCNA3MEN1KMT2AALDH1A1 | |
| SCHEMBL3897406 | 0.81 | KCNA3 (0.81) | KCNA3MEN1KMT2AALDH1A1 | |
| SCHEMBL3455503 | 0.81 | MEN1 (1.00) | KCNA3MEN1KMT2AALDH1A1 | |
| SCHEMBL6437618 | 0.80 | MEN1 (0.80) | KCNA3MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1143965-B1 | CARBOCYCLIC POTASSIUM CHANNEL INHIBITORS | MERCK & CO INC (US) | 2009-02-25 | — | — | EP | disclosed |
| US-6632836-B1 | To treat autoimmune disorders, cardiac arrhythmias and the like | MERCK & CO., INC. | 2003-10-14 | — | — | US | disclosed |
| EP-1143965-A4 | CARBOCYCLIC POTASSIUM CHANNEL INHIBITORS | MERCK & CO INC (US) | 2002-10-09 | — | — | EP | disclosed |
| EP-1143965-A1 | CARBOCYCLIC POTASSIUM CHANNEL INHIBITORS | Merck & Co., Inc. (US) | 2001-10-17 | — | — | EP | disclosed |
| WO-2000025770-A1 | CARBOCYCLIC POTASSIUM CHANNEL INHIBITORS | MERCK & CO., INC. (US) | 2000-05-11 | — | — | WO | disclosed |