Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 20/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL3655895 | 0.84 | GSK3B (0.53) | GSK3B | |
| SCHEMBL1833809 | 0.83 | GSK3B (0.47) | GSK3B | |
| SCHEMBL3662162 | 0.83 | GSK3B (0.54) | GSK3B | |
| SCHEMBL1833092 | 0.82 | GSK3B (0.47) | GSK3B | |
| SCHEMBL3659663 | 0.79 | GSK3B (0.51) | GSK3B | |
| SCHEMBL3664997 | 0.77 | GSK3B (0.48) | GSK3B | |
| SCHEMBL1832106 | 0.75 | GSK3B (0.49) | GSK3B | |
| Bromide SCHEMBL1831381 | 0.75 | GSK3B (0.45) | GSK3B | |
| SCHEMBL1840230 | 0.73 | GSK3B (0.45) | GSK3B | |
| SCHEMBL1834667 | 0.72 | GSK3B (0.51) | GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009156864-A2 | SUBSTITUTED ALKYL PYRIMIDIN-4-ONE DERIVATIVES | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2009-12-30 | — | — | WO | disclosed |