Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 13/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 13/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 13/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 11/20 | 0.43 |
| ▸ | ATR | Q13535 | 6/20 | 0.43 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3461741 | 0.74 | PIK3CD (0.55) | PIK3CDPIK3CAPIK3CGPIK3CBATR | |
| SCHEMBL3907494 | 0.74 | ATR (0.47) | PIK3CDPIK3CAPIK3CGPIK3CBATR | |
| SCHEMBL3907501 | 0.74 | ATR (0.47) | PIK3CDPIK3CAPIK3CGPIK3CBATR | |
| SCHEMBL4251691 | 0.73 | PIK3CD (0.50) | PIK3CDPIK3CAPIK3CGPIK3CBATR | |
| SCHEMBL3461543 | 0.70 | PIK3CD (0.60) | PIK3CDPIK3CAPIK3CGPIK3CBATR | |
| SCHEMBL3459905 | 0.70 | ATR (0.74) | PIK3CDPIK3CAPIK3CGPIK3CBATR | |
| SCHEMBL3461458 | 0.70 | PIK3CD (0.56) | PIK3CDPIK3CAPIK3CGPIK3CBATR | |
| SCHEMBL3462514 | 0.69 | PIK3CD (0.65) | PIK3CDPIK3CAPIK3CGPIK3CBATR | |
| SCHEMBL3462245 | 0.69 | ATR (0.58) | PIK3CDPIK3CAPIK3CGPIK3CBATR | |
| SCHEMBL3460861 | 0.69 | PIK3CD (0.54) | PIK3CDPIK3CAPIK3CGPIK3CBATR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501514-A4 | PROTEIN KINASE MODULATORS AND METHODS OF USE | EXELIXIS INC (US) | 2009-08-26 | — | — | EP | disclosed |
| EP-1501514-A2 | PROTEIN KINASE MODULATORS AND METHODS OF USE | Exelixis, Inc. (US) | 2005-02-02 | — | — | EP | disclosed |
| WO-2003093297-A2 | PROTEIN KINASE MODULATORS AND METHODS OF USE | EXELIXIS, INC. (US) | 2003-11-13 | — | — | WO | disclosed |