Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | CA14 | Q9ULX7 | 4/20 | 0.33 |
| ▸ | CA12 | O43570 | 3/20 | 0.33 |
| ▸ | CA1 | P00915 | 3/20 | 0.32 |
| ▸ | CA7 | P43166 | 2/20 | 0.32 |
| ▸ | CA2 | P00918 | 2/20 | 0.32 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12261426 | 0.76 | HDAC6 (0.36) | USP30HDAC6HDAC1HDAC2CA14 | |
| SCHEMBL16440494 | 0.76 | HDAC6 (0.36) | USP30HDAC6HDAC1HDAC2CA14 | |
| SCHEMBL28732955 | 0.76 | HDAC6 (0.33) | USP30HDAC6HDAC1HDAC2CA14 | |
| SCHEMBL5345861 | 0.74 | AAK1 (0.35) | USP30HDAC6HDAC1HDAC2CA14 | |
| SCHEMBL1028060 | 0.74 | POLB (0.45) | USP30HDAC6HDAC1HDAC2CA14 | |
| SCHEMBL19492022 | 0.74 | USP30 (0.35) | USP30HDAC6HDAC1HDAC2CA14 | |
| SCHEMBL22308401 | 0.73 | CA1 (0.36) | USP30HDAC6HDAC1HDAC2CA14 | |
| SCHEMBL1494389 | 0.73 | HDAC6 (0.34) | USP30HDAC6HDAC1HDAC2CA14 | |
| SCHEMBL6583642 | 0.73 | HDAC6 (0.38) | HDAC6HDAC1HDAC2CA14CA12 | |
| SCHEMBL5345858 | 0.73 | HDAC6 (0.34) | USP30HDAC6HDAC1HDAC2CA14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2018371-A1 | PRIMARY AMINES AND DERIVATIVES THEREOF AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | Arena Pharmaceuticals, Inc. (US) | 2009-01-28 | — | — | EP | disclosed |
| WO-2007136703-A1 | PRIMARY AMINES AND DERIVATIVES THEREOF AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2007-11-29 | — | — | WO | disclosed |