⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3908740 | 0.89 | IGF1R (0.32) | — | |
| SCHEMBL400354 | 0.87 | — | — | |
| SCHEMBL11895447 | 0.81 | AHR (0.33) | — | |
| SCHEMBL3908997 | 0.80 | — | — | |
| SCHEMBL402100 | 0.79 | AHR (0.33) | — | |
| SCHEMBL399956 | 0.79 | AHR (0.32) | — | |
| SCHEMBL401270 | 0.78 | IGF1R (0.33) | — | |
| SCHEMBL401187 | 0.77 | IGF1R (0.36) | — | |
| SCHEMBL401747 | 0.77 | IGF1R (0.38) | — | |
| SCHEMBL401086 | 0.77 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7534797-B2 | 6,6-Bicyclic ring substituted heterobicyclic protein kinase inhibitors | OSI PHARMACEUTICALS, INC. (US) | 2009-05-19 | — | — | US | disclosed |
| US-20060235031-A1 | 6,6-Bicyclic ring substituted heterobicyclic protein kinase inhibitors | ACERTA PHARMA B.V. (NL) | 2006-10-19 | — | — | US | disclosed |