Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.63 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.50 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.47 |
| ▸ | ESR1 | P03372 | 1/20 | 0.46 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.45 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.45 |
| ▸ | F10 | P00742 | 2/20 | 0.44 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | PTAFR | P25105 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12287671 | 0.82 | NOTUM (0.65) | NOTUMHRH3DPP7ESR1ESR2 | |
| SCHEMBL3895820 | 0.82 | ESR2 (0.66) | NOTUMHRH3ESR1ESR2NR1H2 | |
| SCHEMBL8221038 | 0.81 | NOTUM (0.63) | NOTUMHRH3ESR1ESR2MCHR1 | |
| SCHEMBL4518190 | 0.81 | NOTUM (0.63) | NOTUMHRH3DPP7ESR1ESR2 | |
| SCHEMBL6188423 | 0.81 | NOTUM (0.63) | NOTUMHRH3ESR1ESR2NR1H2 | |
| SCHEMBL397687 | 0.81 | NR1H2 (0.66) | NOTUMHRH3ESR1ESR2NR1H2 | |
| SCHEMBL30575058 | 0.81 | NOTUM (0.63) | NOTUMHRH3DPP7ESR1ESR2 | |
| SCHEMBL30561545 | 0.81 | NR1H2 (0.66) | NOTUMHRH3ESR1ESR2NR1H2 | |
| SCHEMBL2616863 | 0.80 | ESR1 (0.72) | NOTUMDPP7ESR1ESR2AKR1C3 | |
| SCHEMBL1365173 | 0.80 | NR1H2 (0.72) | DPP7ESR1ESR2NR1H2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1654251-A4 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2009-03-11 | — | — | EP | disclosed |
| US-20060205740-A1 | Chemical compounds | SMITHKLINE BEECHAM CORPORATION | 2006-09-14 | — | — | US | disclosed |
| EP-1654251-A1 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-05-10 | — | — | EP | disclosed |
| WO-2005016914-A1 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-02-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060205740-A1 | Chemical compounds | ERBB2, ERBB4, ERBB3 | NOTUM 1782/4885HRH3 1546/4885DPP7 1499/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.