SCHEMBL3909730

SCHEMBL3909730

Cc1[c]ccc(C)c1F

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL455383 0.79
SCHEMBL466380 0.79
SCHEMBL17023613 0.75
SCHEMBL17698453 0.75
SCHEMBL2351350 0.75
SCHEMBL2347896 0.75
SCHEMBL10677998 0.75
SCHEMBL125358 0.72
SCHEMBL17698455 0.72
SCHEMBL14871725 0.69 PDE3B (0.34)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 66 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2914575-B1 PLASMINOGEN ACTIVATOR-1 INHIBITORS AND METHODS OF USE THEREOF UNIV MICHIGAN REGENTS (US) 2020-10-14 EP claimed
US-9718760-B2 Plasminogen activator inhibitor-1 inhibitors and methods of use thereof THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 2017-08-01 US claimed
CN-1847229-B 2,4,8- trisubstituted-8H- pyridine[2,3-d] pyridine -7-one compound SMITHKLINE BEECHAM CORP 2011-05-04 CN claimed
CN-1847229-A Novel compounds SMITHKLINE BEECHAM CORP (US) 2006-10-18 CN claimed
EP-1053224-B1 BIPHENYLSULFONYL CYANAMIDES, METHOD FOR THE PRODUCTION THEREOF AND THEIR UTILIZATION AS A MEDICAMENT AVENTIS PHARMA GMBH (DE) 2002-08-21 EP claimed
US-6369069-B1 CARDIOVASCULAR DISORDERS AVENTIS PHARMA DEUTSCHLAND GMBH (DE) 2002-04-09 US claimed
EP-0658552-B1 Process for the preparation of alpha-tocopherol derivatives EISAI CO LTD (JP) 1999-03-31 EP claimed
US-5532387-A CYCLIZATION OF TRIMETHYLHYDROQUINONE AND AN ALKENYL ALCOHOL, REUSABLE CATALYST, IIIB FLUOROSULFONATE, NITRATE, SULFATE, OR FLUOROALKYLSULFONATE EISAI CO., LTD. (JP) 1996-07-02 US claimed
EP-0658552-A1 Process for the preparation of alpha-tocopherol derivatives Eisai Co., Ltd. (JP) 1995-06-21 EP claimed
US-4567197-A THORMBOXANE A2 ANTAGONISTS IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1986-01-28 US claimed
EP-2914575-B1 PLASMINOGEN ACTIVATOR-1 INHIBITORS AND METHODS OF USE THEREOF UNIV MICHIGAN REGENTS (US) 2020-10-14 EP disclosed
EP-3045450-B1 INTERMEDIATE COMPOUNDS IN PROCESSES FOR PRODUCING PYRIDAZINONE COMPOUNDS SUMITOMO CHEMICAL CO (JP) 2018-02-07 EP disclosed
US-20170291893-A1 PLASMINOGEN ACTIVATOR INHIBITOR-1 INHIBITORS AND METHODS OF USE THEREOF EASTERN MICHIGAN UNIVERSITY 2017-10-12 US disclosed
US-9718760-B2 Plasminogen activator inhibitor-1 inhibitors and methods of use thereof THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 2017-08-01 US disclosed
EP-3045450-A1 INTERMEDIATE COMPOUNDS IN A PROCESS FOR PRODUCING PYRIDAZINONE COMPOUNDS SUMITOMO CHEMICAL CO., LTD. (JP) 2016-07-20 EP disclosed
US-4567197-A THORMBOXANE A2 ANTAGONISTS IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1986-01-28 US disclosed
EP-0067217-A4 COMPOSITIONS OF POLYPHENYLENE OXIDES WITH EPDM-SILICONE RUBBER. GEN ELECTRIC (US) 1983-05-16 EP disclosed
EP-0067217-A1 COMPOSITIONS OF POLYPHENYLENE OXIDES WITH EPDM-SILICONE RUBBER GENERAL ELECTRIC COMPANY (US) 1982-12-22 EP disclosed
US-4365042-A Compositions of polyphenylene oxides with EPDM-silicone rubber GENERAL ELECTRIC COMPANY (US) 1982-12-21 US disclosed
WO-1982002204-A1 COMPOSITIONS OF POLYPHENYLENE OXIDES WITH EPDM-SILICONE RUBBER GEN ELECTRIC (US) 1982-07-08 WO disclosed