Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 6/20 | 0.62 |
| ▸ | GSK3A | P49840 | 5/20 | 0.53 |
| ▸ | AURKA | O14965 | 4/20 | 0.53 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | PTK2B | Q14289 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | PLK1 | P53350 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1917779 | 0.89 | GSK3B (0.48) | GSK3BGSK3AAURKAMAPTMEN1 | |
| SCHEMBL1917393 | 0.89 | AURKA (0.56) | GSK3BGSK3AAURKAMAPTMEN1 | |
| SCHEMBL1916351 | 0.88 | STK17A (0.53) | GSK3BGSK3AAURKAPIN1MAPT | |
| SCHEMBL1917614 | 0.88 | MERTK (0.47) | GSK3BGSK3AAURKAMAPTMEN1 | |
| SCHEMBL1916888 | 0.88 | GSK3B (0.47) | GSK3BGSK3AAURKAALDH1A1MAPT | |
| SCHEMBL1917454 | 0.88 | GSK3B (0.47) | GSK3BGSK3AAURKAPIN1ALDH1A1 | |
| SCHEMBL1917553 | 0.87 | CDK2 (0.53) | GSK3BALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL1916151 | 0.87 | GSK3B (0.62) | GSK3BGSK3AAURKAALDH1A1MAPT | |
| SCHEMBL1918193 | 0.86 | SYK (0.51) | GSK3BGSK3AAURKACDK1CDK2 | |
| SCHEMBL1918362 | 0.86 | EGFR (0.48) | GSK3BGSK3AAURKAKDRCDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7588899-B2 | Fluorescent probes for use in protein kinase inhibitor binding assay | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2009-09-15 | — | — | US | disclosed |
| US-7588899-B2 | Fluorescent probes for use in protein kinase inhibitor binding assay | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2009-09-15 | — | — | US | disclosed |
| EP-1670789-B1 | FLUORESCENT PROBES FOR USE IN PROTEIN KINASE INHIBITOR BINDING ASSAY | BOEHRINGER INGELHEIM PHARMA (US) | 2008-11-19 | — | — | EP | disclosed |
| EP-1670789-B1 | FLUORESCENT PROBES FOR USE IN PROTEIN KINASE INHIBITOR BINDING ASSAY | BOEHRINGER INGELHEIM PHARMA (US) | 2008-11-19 | — | — | EP | disclosed |
| US-20060263841-A1 | Fluorescent probes for use in protein kinase inhibitor binding assay | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2006-11-23 | — | — | US | disclosed |
| US-7125996-B2 | Fluorescent probes for use in protein kinase inhibitor binding assay | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2006-10-24 | — | — | US | disclosed |
| EP-1670789-A2 | FLUORESCENT PROBES FOR USE IN PROTEIN KINASE INHIBITOR BINDING ASSAY | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2006-06-21 | — | — | EP | disclosed |
| US-20050100978-A1 | Fluorescent probes for use in protein kinase inhibitor binding assay | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2005-05-12 | — | — | US | disclosed |
| WO-2005033330-A2 | FLUORESCENT PROBES FOR USE IN PROTEIN KINASE INHIBITOR BINDING ASSAY | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2005-04-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060263841-A1 | Fluorescent probes for use in protein kinase inhibitor binding assay | MAP4K5, MAP3K5, MAP3K20 | GSK3B 1017/4885GSK3A 844/4885AURKA 135/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.