Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 9/20 | 0.63 |
| ▸ | HRH2 | P25021 | 8/20 | 0.63 |
| ▸ | HRH3 | Q9Y5N1 | 9/20 | 0.59 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.54 |
| ▸ | HTR2A | P28223 | 1/20 | 0.54 |
| ▸ | HTR7 | P34969 | 1/20 | 0.54 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3912540 | 0.89 | HRH2 (0.60) | HRH1HRH2HRH3ADORA3HTR2A | |
| SCHEMBL2850901 | 0.83 | HRH3 (0.63) | HRH1HRH3 | |
| SCHEMBL5742310 | 0.82 | HRH3 (0.64) | HRH1HRH2HRH3HTR2AHTR7 | |
| SCHEMBL3910347 | 0.81 | HRH1 (0.48) | HRH1HRH2HRH3ADORA3HTR2A | |
| SCHEMBL4695112 | 0.80 | HRH3 (0.68) | HRH1HRH3 | |
| SCHEMBL4695557 | 0.80 | HRH3 (0.68) | HRH1HRH3 | |
| SCHEMBL12061373 | 0.79 | HRH3 (0.90) | HRH3 | |
| SCHEMBL4695509 | 0.79 | HRH3 (0.67) | HRH1HRH3 | |
| SCHEMBL3912848 | 0.77 | HRH2 (0.46) | HRH1HRH2HRH3ADORA3HTR2A | |
| SCHEMBL492219 | 0.75 | HRH3 (0.75) | HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2027108-A1 | HISTAMINE RECEPTOR ANTAGONISTS COMPRISING AN AZEPIN CORE | Glaxo Group Limited (GB) | 2009-02-25 | — | — | EP | disclosed |
| WO-2007135081-A1 | HISTAMINE RECEPTOR ANTAGONISTS COMPRISING AN AZEPIN CORE | GLAXO GROUP LIMITED (GB) | 2007-11-29 | — | — | WO | disclosed |