Sugi Predict

Sugi Predict / Compounds / SCHEMBL3915201

SCHEMBL3915201

SCHEMBL3915201

CC(CCCN1CCN(c2ccncc2)C1=O)COc1ccc(-c2ccc(Cl)cc2)cc1

nearest known ligand 0.72

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
▸ LARS1 Q9P2J5 1/20 0.72
▸ KCNH2 Q12809 3/20 0.52
▸ HRH1 P35367 3/20 0.46
▸ HRH3 Q9Y5N1 3/20 0.46
▸ HRH2 P25021 2/20 0.46
▸ DRD2 P14416 2/20 0.43
▸ ITGB3 P05106 1/20 0.41
▸ ITGA2B P08514 1/20 0.41
▸ DRD3 P35462 1/20 0.41
▸ CYP1A1 P04798 1/20 0.39
▸ SIGMAR1 Q99720 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13899050 0.90 LARS1 (0.58) LARS1KCNH2HRH1HRH3HRH2
SCHEMBL13899055 0.90 LARS1 (0.59) LARS1KCNH2HRH1HRH3HRH2
SCHEMBL13898782 0.87 LARS1 (0.55) LARS1KCNH2HRH1HRH3HRH2
SCHEMBL3921023 0.85 LARS1 (0.73) LARS1KCNH2HRH1HRH3HRH2
SCHEMBL3912065 0.85 LARS1 (0.73) LARS1KCNH2HRH1HRH3HRH2
SCHEMBL3914826 0.85 LARS1 (0.70) LARS1KCNH2HRH1HRH3HRH2
SCHEMBL3913269 0.85 LARS1 (0.73) LARS1KCNH2HRH1HRH3HRH2
SCHEMBL13899035 0.84 LARS1 (0.51) LARS1KCNH2DRD2ITGB3ITGA2B
SCHEMBL13898737 0.84 LARS1 (0.51) LARS1KCNH2DRD2ITGB3ITGA2B
SCHEMBL3913145 0.83 LARS1 (0.70) LARS1KCNH2HRH1HRH3HRH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7501445-B2 Imidazolidinone compounds NATIONAL HEALTH RESEARCH INSTITUTES (TW) 2009-03-10 — — US disclosed
US-7501445-B2 Imidazolidinone compounds NATIONAL HEALTH RESEARCH INSTITUTES (TW) 2009-03-10 — — US disclosed
US-7501445-B2 Imidazolidinone compounds NATIONAL HEALTH RESEARCH INSTITUTES (TW) 2009-03-10 — — US disclosed
US-20070049623-A1 Imidazolidinone compounds NATIONAL HEALTH RESEARCH INSTITUTES, A TAIWAN CORPORATION 2007-03-01 — — US disclosed
US-20070049623-A1 Imidazolidinone compounds NATIONAL HEALTH RESEARCH INSTITUTES, A TAIWAN CORPORATION 2007-03-01 — — US disclosed
US-20070049623-A1 Imidazolidinone compounds NATIONAL HEALTH RESEARCH INSTITUTES, A TAIWAN CORPORATION 2007-03-01 — — US disclosed
US-7129359-B2 Imidazolidinone compounds NATIONAL HEALTH RESEARCH INSTITUTES (TW) 2006-10-31 — — US disclosed
US-20040116476-A1 for treating infection by enterovirus of the Picornaviridae family ; exemplified by: 1-[2-(4'-Chloro-biphenyl-4-yloxymethyl)-benzyl]-3-pyridin-4-yl-imidazolidin-2-one NATIONAL HEALTH RESEARCH INSTITUTES (TW) 2004-06-17 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070049623-A1 Imidazolidinone compounds PKN2, PKN1, EIF2AK2 LARS1 4511/4885KCNH2 728/4885HRH1 1058/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.