Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 20/20 | 0.84 |
| ▸ | MTOR | P42345 | 20/20 | 0.84 |
| ▸ | PIK3CG | P48736 | 7/20 | 0.84 |
| ▸ | ATR | Q13535 | 4/20 | 0.84 |
| ▸ | RICTOR | Q6R327 | 1/20 | 0.68 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.68 |
| ▸ | MAPKAP1 | Q9BPZ7 | 1/20 | 0.68 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.68 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4995095 | 0.91 | PIK3CA (1.00) | PIK3CAMTORPIK3CGATRRICTOR | |
| SCHEMBL29789935 | 0.91 | PIK3CA (1.00) | PIK3CAMTORPIK3CGATRRICTOR | |
| SCHEMBL3986205 | 0.91 | PIK3CA (0.82) | PIK3CAMTORPIK3CGATRRICTOR | |
| SCHEMBL3916853 | 0.90 | PIK3CA (0.84) | PIK3CAMTORPIK3CGATRRICTOR | |
| SCHEMBL3983804 | 0.90 | PIK3CA (0.75) | PIK3CAMTORPIK3CGATRRICTOR | |
| SCHEMBL3987169 | 0.89 | PIK3CA (0.83) | PIK3CAMTORPIK3CGATRRICTOR | |
| SCHEMBL3986876 | 0.89 | PIK3CA (0.87) | PIK3CAMTORPIK3CGATRRICTOR | |
| SCHEMBL3991734 | 0.89 | PIK3CA (0.84) | PIK3CAMTORPIK3CGATR | |
| SCHEMBL3986048 | 0.89 | PIK3CA (1.00) | PIK3CAMTORPIK3CGATRRICTOR | |
| SCHEMBL3989695 | 0.89 | PIK3CA (1.00) | PIK3CAMTORPIK3CGATRRICTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2078021-A2 | PYRAZOLOPYRIMIDINE ANALOGS AND THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS | Wyeth a Corporation of the State of Delaware (US) | 2009-07-15 | — | — | EP | claimed |
| WO-2008115974-A2 | PYRAZOLOPYRIMIDINE ANALOGS AND THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS | WYETH (US) | 2008-09-25 | — | — | WO | claimed |