Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.55 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.55 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.55 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.55 |
| ▸ | CFTR | P13569 | 3/20 | 0.47 |
| ▸ | AURKA | O14965 | 3/20 | 0.47 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.47 |
| ▸ | SUV39H2 | Q9H5I1 | 10/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.44 |
| ▸ | NOS1 | P29475 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4121554 | 1.00 | PDE4A (0.55) | PDE4APDE4BPDE4CPDE4DCFTR | |
| SCHEMBL3921361 | 1.00 | PDE4A (0.55) | PDE4APDE4BPDE4CPDE4DCFTR | |
| SCHEMBL3924839 | 0.87 | MAP4K4 (0.47) | PDE4APDE4BPDE4CPDE4DAURKA | |
| SCHEMBL3927951 | 0.87 | MAP4K4 (0.47) | PDE4APDE4BPDE4CPDE4DAURKA | |
| SCHEMBL3929667 | 0.82 | MAP4K4 (0.51) | AURKAPDPK1AURKBSUV39H2MAP4K4 | |
| SCHEMBL8153360 | 0.82 | PDE4A (0.55) | PDE4APDE4BPDE4CPDE4DNOS1 | |
| SCHEMBL8152356 | 0.82 | PDE4A (0.55) | PDE4APDE4BPDE4CPDE4DNOS1 | |
| SCHEMBL4001268 | 0.81 | PDE4A (0.60) | PDE4APDE4BPDE4CPDE4DNOS1 | |
| SCHEMBL8256368 | 0.81 | PDE4A (0.60) | PDE4APDE4BPDE4CPDE4DNOS1 | |
| SCHEMBL3931773 | 0.81 | PDE4A (0.63) | PDE4APDE4BPDE4CPDE4DSUV39H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009003669-A2 | PYRIDO(3,2-D)PYRIMIDINES AND PHARMACEUTICAL COMPOSITIONS USEFUL FOR MEDICAL TREATMENT | 4 AZA IP NV (BE) | 2009-01-08 | — | — | WO | disclosed |