Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 17/20 | 0.51 |
| ▸ | MTOR | P42345 | 5/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.49 |
| ▸ | ATRIP | Q8WXE1 | 5/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.48 |
| ▸ | TAF1 | P21675 | 3/20 | 0.48 |
| ▸ | PIK3R1 | P27986 | 3/20 | 0.48 |
| ▸ | PRKDC | P78527 | 2/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.42 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3926774 | 0.92 | ATR (0.49) | ATRMTORKCNH2ATRIPPIK3CA | |
| SCHEMBL3926442 | 0.90 | MTOR (0.53) | ATRMTORKCNH2ATRIPPIK3CA | |
| SCHEMBL3934684 | 0.90 | PIK3CA (0.51) | ATRMTORKCNH2ATRIPPIK3CA | |
| SCHEMBL3926299 | 0.87 | ATR (0.55) | ATRMTORKCNH2ATRIPPIK3CA | |
| SCHEMBL3932925 | 0.87 | ATR (0.44) | ATRMTORKCNH2ATRIPPIK3CA | |
| SCHEMBL3924871 | 0.86 | PIK3CA (0.54) | ATRMTORKCNH2ATRIPPIK3CA | |
| SCHEMBL3926241 | 0.85 | ATR (0.53) | ATRMTORKCNH2ATRIPPIK3CA | |
| SCHEMBL3935917 | 0.85 | ATR (0.51) | ATRMTORKCNH2ATRIPPIK3CA | |
| SCHEMBL4207140 | 0.84 | ATR (0.51) | ATRMTORKCNH2ATRIPPIK3CA | |
| SCHEMBL3936002 | 0.83 | PIK3CA (0.56) | ATRMTORKCNH2ATRIPPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074118-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | AstraZeneca AB (SE) | 2009-07-01 | — | — | EP | disclosed |
| WO-2009007748-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |