Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 9/20 | 0.56 |
| ▸ | SLC6A2 | P23975 | 7/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9747 | 0.82 | SLC6A4 (0.61) | SLC6A4SLC6A2KMT2AHSD17B10HPGD | |
| SCHEMBL3530 | 0.81 | POLB (0.44) | KMT2AHSD17B10HPGDSMN1; SMN2MEN1 | |
| SCHEMBL1535377 | 0.81 | SLC6A2 (0.56) | SLC6A4SLC6A2KMT2ALMNAMEN1 | |
| SCHEMBL3312531 | 0.81 | SLC6A2 (0.56) | SLC6A4SLC6A2KMT2ALMNAMEN1 | |
| SCHEMBL2741 | 0.81 | SLC6A2 (0.56) | SLC6A4SLC6A2KMT2ALMNAMEN1 | |
| SCHEMBL3563 | 0.80 | SLC6A2 (0.56) | SLC6A4SLC6A2KMT2AHTTOPRM1 | |
| SCHEMBL3901 | 0.80 | SLC6A4 (0.38) | SLC6A4SLC6A2KMT2ATSHRHPGD | |
| SCHEMBL3964 | 0.79 | CACNA2D1 (0.41) | SLC6A4SLC6A2KMT2ATSHRHTT | |
| SCHEMBL3522 | 0.79 | MAPK1 (0.41) | SLC6A4SLC6A2KMT2ASMN1; SMN2MAPT | |
| SCHEMBL3820 | 0.79 | SLC6A4 (0.39) | SLC6A4SLC6A2KMT2ATSHRHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5023269-A | 3-aryloxy-3-substituted propanamines | ELI LILLY AND COMPANY (US) | 1991-06-11 | — | — | US | disclosed |
| EP-0273658-B1 | 3-ARYLOXY-3-SUBSTITUTED PROPANAMINES | ELI LILLY AND COMPANY (US) | 1990-10-31 | — | — | EP | disclosed |
| US-4956388-A | ANTIDEPRESSANTS, ANTIANXIETY, TREATMENT OF OBESITY, ADDICTION TO SMOKING AND ALCOHOL | ELI LILLY AND COMPANY (US) | 1990-09-11 | — | — | US | disclosed |
| EP-0273658-A1 | 3-Aryloxy-3-substituted propanamines | ELI LILLY AND COMPANY (US) | 1988-07-06 | — | — | EP | disclosed |