Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 19/20 | 0.45 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | BCR | P11274 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2085804 | 0.81 | BRAF (0.61) | BRAF | |
| SCHEMBL2083847 | 0.74 | BRAF (0.73) | BRAF | |
| SCHEMBL4023060 | 0.74 | BRAF (0.52) | BRAF | |
| SCHEMBL4020553 | 0.74 | TEK (0.55) | BRAF | |
| SCHEMBL4016675 | 0.74 | BRAF (0.60) | BRAF | |
| SCHEMBL4036488 | 0.73 | STIM1 (0.51) | BRAF | |
| SCHEMBL4021247 | 0.73 | TEK (0.55) | BRAF | |
| SCHEMBL4016744 | 0.73 | BRAF (0.61) | BRAF | |
| SCHEMBL4014587 | 0.72 | BRAF (0.52) | BRAF | |
| SCHEMBL13843742 | 0.72 | BRAF (0.45) | BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2041116-A1 | PHENYL SUBSTITUTED HETEROARYL-DERIVATIVES AND USE THEREOF AS ANTI-TUMOR AGENTS | Boehringer Ingelheim International GmbH (DE) | 2009-04-01 | — | — | EP | claimed |
| WO-2008003770-A1 | PHENYL SUBSTITUTED HETEROARYL-DERIVATIVES AND USE THEREOF AS ANTI-TUMOR AGENTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2008-01-10 | — | — | WO | claimed |
| EP-2041116-A1 | PHENYL SUBSTITUTED HETEROARYL-DERIVATIVES AND USE THEREOF AS ANTI-TUMOR AGENTS | Boehringer Ingelheim International GmbH (DE) | 2009-04-01 | — | — | EP | disclosed |
| WO-2008003770-A1 | PHENYL SUBSTITUTED HETEROARYL-DERIVATIVES AND USE THEREOF AS ANTI-TUMOR AGENTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2008-01-10 | — | — | WO | disclosed |