Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 8/20 | 0.55 |
| ▸ | PARP1 | P09874 | 1/20 | 0.48 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.48 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.48 |
| ▸ | MAOA | P21397 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.46 |
| ▸ | RELA | Q04206 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14066166 | 0.86 | DHODH (0.55) | DHODHPARP1PARP15PARP10NPC1 | |
| SCHEMBL3915670 | 0.74 | DHODH (0.81) | DHODHPARP1PARP15PARP10NPC1 | |
| SCHEMBL3915266 | 0.72 | DHODH (0.77) | DHODHPARP1PARP15PARP10NPC1 | |
| SCHEMBL249112 | 0.72 | DHODH (1.00) | DHODHPARP1PARP15PARP10NPSR1 | |
| SCHEMBL8762690 | 0.71 | DHODH (0.76) | DHODHPARP1PARP15PARP10SMN1; SMN2 | |
| SCHEMBL3924670 | 0.69 | DHODH (0.63) | DHODHPARP1PARP15PARP10GAA | |
| SCHEMBL3917931 | 0.69 | DHODH (0.71) | DHODHPARP1PARP15PARP10NPSR1 | |
| SCHEMBL3917932 | 0.69 | DHODH (0.71) | DHODHPARP1PARP15PARP10NPSR1 | |
| SCHEMBL248368 | 0.69 | DHODH (0.71) | DHODHPARP1PARP15PARP10TP53 | |
| SCHEMBL3919704 | 0.68 | DHODH (0.69) | DHODHPARP1PARP15PARP10TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2093214-A1 | Novel compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents | 4SC AG (DE) | 2009-08-26 | — | — | EP | disclosed |