Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 18/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 16/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.40 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.40 |
| ▸ | KCNA1 | Q09470 | 1/20 | 0.40 |
| ▸ | KCND3 | Q9UK17 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3925233 | 0.91 | KCNA5 (0.52) | KCNA5KCNH2CYP3A4CYP2C9KCNA3 | |
| SCHEMBL3919013 | 0.91 | KCNA5 (0.52) | KCNA5KCNH2CYP3A4CYP2C9KCNA3 | |
| SCHEMBL3926610 | 0.90 | KCNA5 (0.47) | KCNA5KCNH2CYP3A4CYP2C9KCNA3 | |
| SCHEMBL3926333 | 0.90 | KCNA5 (0.45) | KCNA5KCNH2CYP3A4CYP2C9KCNA3 | |
| SCHEMBL3917501 | 0.88 | KCNA5 (0.47) | KCNA5KCNH2CYP3A4CYP2C9KCNA3 | |
| SCHEMBL3916694 | 0.88 | KCNA5 (0.44) | KCNA5KCNH2CYP3A4CYP2C9KCNA3 | |
| SCHEMBL3925144 | 0.87 | KCNA5 (0.45) | KCNA5KCNH2CYP3A4CYP2C9KCNA3 | |
| SCHEMBL3925782 | 0.86 | KCNA5 (0.43) | KCNA5KCNH2CYP3A4CYP2C9KCNA3 | |
| SCHEMBL3925223 | 0.86 | KCNA5 (0.49) | KCNA5KCNH2CYP3A4CYP2C9KCNA3 | |
| SCHEMBL3915076 | 0.85 | KCNA5 (0.42) | KCNA5KCNH2CYP3A4CYP2C9KCNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035392-A1 | IMIDAZOLE KV1. 5 POTASSIUM CHANNEL INHIBITORS | Wyeth a Corporation of the State of Delaware (US) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007149874-A1 | IMIDAZOLIDINONE KV1.5 POTASSIUM CHANNEL INHIBITORS | WYETH (US) | 2007-12-27 | — | — | WO | disclosed |