Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.63 |
| ▸ | LMNA | P02545 | 3/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.63 |
| ▸ | POLB | P06746 | 2/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.63 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3928788 | 0.94 | PTGDR2 (0.63) | ALDH1A1LMNAMAPK1POLBSMN1; SMN2 | |
| SCHEMBL3928709 | 0.92 | TP53 (0.55) | ALDH1A1LMNAMAPK1POLBSMN1; SMN2 | |
| SCHEMBL3929256 | 0.91 | PTGDR2 (0.58) | ALDH1A1LMNAMAPK1POLBSMN1; SMN2 | |
| SCHEMBL3937820 | 0.91 | PTGDR2 (0.58) | ALDH1A1LMNAMAPK1POLBSMN1; SMN2 | |
| SCHEMBL3927277 | 0.90 | PTGDR2 (0.69) | ALDH1A1PTGDR2TP53KDM4E | |
| SCHEMBL3929027 | 0.90 | PTGDR2 (0.58) | PTGDR2 | |
| SCHEMBL3931497 | 0.90 | PTGDR2 (0.71) | ALDH1A1LMNAMAPK1POLBSMN1; SMN2 | |
| SCHEMBL3932780 | 0.89 | PTGDR2 (0.56) | ALDH1A1LMNAMAPK1POLBSMN1; SMN2 | |
| SCHEMBL3927677 | 0.89 | PTGDR2 (0.57) | ALDH1A1LMNAMAPK1POLBSMN1; SMN2 | |
| SCHEMBL3939464 | 0.88 | PTGDR2 (0.59) | PTGDR2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044044-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2009-04-08 | — | — | EP | claimed |
| WO-2007143745-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2007-12-13 | — | — | WO | claimed |
| EP-2044044-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2009-04-08 | — | — | EP | disclosed |
| WO-2007143745-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2007-12-13 | — | — | WO | disclosed |
| WO-2007143745-A2 | SUBSTITUTED PHENYL ACETIC ACIDS AS DP-2 ANTAGONISTS | ICOS CORPORATION (US) | 2007-12-13 | — | — | WO | disclosed |