Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 2/20 | 0.59 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.58 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3932361 | 0.93 | CHRNA7 (0.55) | CHRNA7CHRNB2CHRNA4KCNH2 | |
| SCHEMBL3934161 | 0.90 | CHRNA7 (0.60) | CHRNA7CHRNB2CHRNA4KCNH2 | |
| SCHEMBL3927284 | 0.86 | CHRNA7 (0.63) | CHRNA7CHRNB2CHRNA4KCNH2 | |
| SCHEMBL3929869 | 0.84 | CHRNA7 (0.60) | CHRNA7KCNH2 | |
| SCHEMBL3927133 | 0.83 | CHRNA7 (0.60) | CHRNA7CHRNB2CHRNA4KCNH2 | |
| SCHEMBL3934168 | 0.83 | CHRNA7 (0.63) | CHRNA7CHRNB2CHRNA4KCNH2 | |
| SCHEMBL3932381 | 0.83 | CHRNA7 (0.60) | CHRNA7CHRNB2CHRNA4KCNH2 | |
| SCHEMBL3932363 | 0.83 | CHRNA7 (0.57) | CHRNA7CHRNB2CHRNA4KCNH2 | |
| SCHEMBL3935984 | 0.83 | CHRNA7 (0.57) | CHRNA7CHRNB2CHRNA4KCNH2 | |
| SCHEMBL3940691 | 0.83 | CHRNA7 (0.67) | CHRNA7CHRNB2CHRNA4KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044038-A2 | NOVEL PIPERAZINES, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE THEREOF | Cornerstone Therapeutics Inc. (US) | 2009-04-08 | — | — | EP | claimed |
| WO-2007146066-A2 | NOVEL PIPERAZINES, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE THEREOF | CRITICAL THERAPEUTICS, INC. (US) | 2007-12-21 | — | — | WO | claimed |
| EP-2044038-A2 | NOVEL PIPERAZINES, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE THEREOF | Cornerstone Therapeutics Inc. (US) | 2009-04-08 | — | — | EP | disclosed |
| WO-2007146066-A2 | NOVEL PIPERAZINES, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE THEREOF | CRITICAL THERAPEUTICS, INC. (US) | 2007-12-21 | — | — | WO | disclosed |