Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 19/20 | 0.57 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL391990 | 0.89 | MAP2K1 (0.58) | MAP2K1MAP2K2ALOX15TSHR | |
| SCHEMBL15700930 | 0.79 | MAP2K1 (0.70) | MAP2K1MAP2K2ALOX15TSHR | |
| SCHEMBL391367 | 0.77 | MAP2K1 (0.59) | MAP2K1MAP2K2ALOX15TSHR | |
| SCHEMBL393120 | 0.77 | MAP2K1 (0.58) | MAP2K1MAP2K2ALOX15TSHR | |
| SCHEMBL12899190 | 0.77 | MAP2K1 (0.43) | MAP2K1 | |
| SCHEMBL391996 | 0.77 | MAP2K1 (0.53) | MAP2K1MAP2K2ALOX15TSHR | |
| SCHEMBL1516547 | 0.76 | MAP2K1 (0.71) | MAP2K1MAP2K2ALOX15TSHR | |
| SCHEMBL10195311 | 0.75 | MAP2K1 (0.54) | MAP2K1MAP2K2 | |
| Hydrochloric Acid SCHEMBL388702 | 0.74 | MAP2K1 (0.53) | MAP2K1MAP2K2 | |
| SCHEMBL1516511 | 0.74 | MAP2K1 (0.64) | MAP2K1MAP2K2ALOX15TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 96 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8268852-B2 | Heterocyclic inhibitors of MEK and methods of use thereof | ARRAY BIOPHARMA INC. (US) | 2012-09-18 | — | — | US | claimed |
| US-20090143579-A1 | Heterocyclic Inhibitors of MEK and Methods of Use Thereof | ARRAY BIOPHARMA INC. (US) | 2009-06-04 | — | — | US | claimed |
| US-20080251411-A1 | Lid Sheet For Use in a Blister Pack | ALCAN TECHNOLOGY & MANAGEMENT LTD. (CH) | 2008-10-16 | — | — | US | claimed |
| EP-1928654-A2 | LID SHEET FOR USE IN A BLISTER PACK | GLAXO GROUP LIMITED (GB) | 2008-06-11 | — | — | EP | claimed |
| WO-2007038488-A2 | LID SHEET FOR USE IN A BLISTER PACK | GLAXO GROUP LIMITED (GB) | 2007-04-05 | — | — | WO | claimed |
| US-7017628-B2 | Ecologically friendly funnel | CALIFORNIA PACIFIC LAB, INC. (US) | 2006-03-28 | — | — | US | claimed |
| US-20050263210-A1 | Ecologically friendly funnel | CALIFORNIA PACIFIC LAB, INC. | 2005-12-01 | — | — | US | claimed |
| WO-2019112138-A1 | METHOD FOR PREPARING BIO-FILLER TO BE ADDED TO PLASTIC, AND BIO-FILLER TO BE ADDED TO PLASTIC, PREPARED THEREBY | 주식회사 리그넘 | 2019-06-13 | — | — | WO | disclosed |
| EP-2251327-B1 | HETEROCYCLIC INHIBITORS OF MEK | ARRAY BIOPHARMA INC (US) | 2014-02-12 | — | — | EP | disclosed |
| EP-2251327-B1 | HETEROCYCLIC INHIBITORS OF MEK | ARRAY BIOPHARMA INC (US) | 2014-02-12 | — | — | EP | disclosed |
| CN-103333162-A | Viral polymerase inhibitors | BOEHRINGER INGELHEIM INT | 2013-10-02 | — | — | CN | disclosed |
| CN-103319464-A | Viral polymerase inhibitors | BOEHRINGER INGELHEIM INT | 2013-09-25 | — | — | CN | disclosed |
| CN-103304541-A | Viral polymerase inhibitors | BOEHRINGER INGELHEIM INT | 2013-09-18 | — | — | CN | disclosed |
| US-7017628-B2 | Ecologically friendly funnel | CALIFORNIA PACIFIC LAB, INC. (US) | 2006-03-28 | — | — | US | disclosed |
| US-20050263210-A1 | Ecologically friendly funnel | CALIFORNIA PACIFIC LAB, INC. | 2005-12-01 | — | — | US | disclosed |
| US-20050256123-A1 | Heterocyclic inhibitors of MEK and methods of use thereof | ARRAY BIOPHARMA INC. | 2005-11-17 | — | — | US | disclosed |
| US-20050250782-A1 | Heterocyclic inhibitors of MEK and methods of use thereof | ARRAY BIOPHARMA INC. | 2005-11-10 | — | — | US | disclosed |
| WO-2005051301-A2 | HETEROCYCLIC INHIBITORS OF MEK AND METHODS OF USE THEREOF | ARRAY BIOPHARMA INC. (US) | 2005-06-09 | — | — | WO | disclosed |
| US-20020192036-A1 | Erosion control mats | HEI LLC | 2002-12-19 | — | — | US | disclosed |
| US-4874656-A | POLYESTER, POLYPROPYLENE, AND METALLIC FOIL; VAPOR AND GAS IMPERMEABILITY; FIREARMS | A. AHLSTRON CORPORATION (FI) | 1989-10-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050250782-A1 | Heterocyclic inhibitors of MEK and methods of use thereof | NRAS, BRAF, MAPK9 | MAP2K1 87/4885MAP2K2 73/4885ALOX15 1476/4885 |
| US-20090143579-A1 | Heterocyclic Inhibitors of MEK and Methods of Use Thereof | NRAS, BRAF, MAPK9 | MAP2K1 85/4885MAP2K2 69/4885ALOX15 1593/4885 |
| US-20050256123-A1 | Heterocyclic inhibitors of MEK and methods of use thereof | NRAS, BRAF, MAPK9 | MAP2K1 82/4885MAP2K2 69/4885ALOX15 1561/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.