Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 14/20 | 0.36 |
| ▸ | KDR | P35968 | 5/20 | 0.33 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.32 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.32 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.32 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.32 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3927416 | 1.00 | MAPK14 (0.36) | MAPK14KDRMAPK13MAPK12MAPK11 | |
| SCHEMBL3926763 | 0.91 | DPP4 (0.36) | MAPK14KDRDPP4FGFR1EPHB4 | |
| SCHEMBL3922932 | 0.90 | KDR (0.39) | MAPK14KDRFGFR1EPHB4 | |
| SCHEMBL3927419 | 0.89 | KDR (0.33) | MAPK14KDRDPP4FGFR1EPHB4 | |
| SCHEMBL14395970 | 0.86 | KDR (0.32) | MAPK14KDRFGFR1EPHB4 | |
| SCHEMBL5914158 | 0.85 | MAPK14 (0.36) | MAPK14KDRMAPK13MAPK12MAPK11 | |
| SCHEMBL5914154 | 0.85 | MAPK14 (0.36) | MAPK14KDRMAPK13MAPK12MAPK11 | |
| SCHEMBL5914280 | 0.85 | MAPK14 (0.36) | MAPK14KDRMAPK13MAPK12MAPK11 | |
| SCHEMBL5914217 | 0.82 | MAPK14 (0.37) | MAPK14KDRMAPK13MAPK12MAPK11 | |
| SCHEMBL5913882 | 0.82 | MAPK14 (0.37) | MAPK14KDRMAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2041118-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE | Amgen, Inc (US) | 2009-04-01 | — | — | EP | disclosed |
| WO-2007114827-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2007-10-11 | — | — | WO | disclosed |