Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 20/20 | 0.54 |
| ▸ | CCNE2 | O96020 | 7/20 | 0.54 |
| ▸ | CCNE1 | P24864 | 7/20 | 0.54 |
| ▸ | CDK2 | P24941 | 7/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1269899 | 1.00 | IGF1R (0.54) | IGF1RCCNE2CCNE1CDK2 | |
| SCHEMBL1269742 | 0.91 | IGF1R (0.53) | IGF1RCCNE2CCNE1CDK2 | |
| SCHEMBL1269235 | 0.90 | IGF1R (0.60) | IGF1RCCNE2CCNE1CDK2 | |
| SCHEMBL1270104 | 0.90 | IGF1R (0.56) | IGF1RCCNE2CCNE1CDK2 | |
| SCHEMBL1268963 | 0.90 | IGF1R (0.56) | IGF1RCCNE2CCNE1CDK2 | |
| SCHEMBL1269754 | 0.90 | IGF1R (0.59) | IGF1RCCNE2CCNE1CDK2 | |
| SCHEMBL1269100 | 0.89 | IGF1R (0.66) | IGF1RCCNE2CCNE1CDK2 | |
| SCHEMBL15810234 | 0.89 | IGF1R (0.66) | IGF1RCCNE2CCNE1CDK2 | |
| SCHEMBL1269483 | 0.89 | IGF1R (0.66) | IGF1RCCNE2CCNE1CDK2 | |
| SCHEMBL1269162 | 0.89 | IGF1R (0.69) | IGF1RCCNE2CCNE1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2041138-A2 | PYRROLOTRIAZINE KINASE INHIBITORS | Brystol-Myers Squibb Company (US) | 2009-04-01 | — | — | EP | claimed |
| WO-2008005956-A2 | PYRROLOTRIAZINE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-01-10 | — | — | WO | claimed |
| EP-2041138-A2 | PYRROLOTRIAZINE KINASE INHIBITORS | Brystol-Myers Squibb Company (US) | 2009-04-01 | — | — | EP | disclosed |
| WO-2008005956-A2 | PYRROLOTRIAZINE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-01-10 | — | — | WO | disclosed |