Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 15/20 | 0.65 |
| ▸ | BTK | Q06187 | 3/20 | 0.53 |
| ▸ | LCK | P06239 | 2/20 | 0.53 |
| ▸ | BLK | P51451 | 2/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.50 |
| ▸ | ABL1 | P00519 | 1/20 | 0.50 |
| ▸ | KIT | P10721 | 1/20 | 0.50 |
| ▸ | SRC | P12931 | 1/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3930169 | 0.90 | CSF1R (0.62) | BRAFCYP2C9MAPK14 | |
| SCHEMBL3932420 | 0.87 | BRAF (0.54) | BRAFBTKLCKBLKABL1 | |
| SCHEMBL3938207 | 0.86 | BRAF (0.72) | BRAFBTKLCKCYP2C9ABL1 | |
| SCHEMBL3939560 | 0.84 | BRAF (0.74) | BRAFBTKBLKKITMAPK14 | |
| SCHEMBL3934373 | 0.84 | BRAF (0.71) | BRAFBTKLCKCYP2C9ABL1 | |
| SCHEMBL4175332 | 0.83 | BRAF (0.67) | BRAFBTKLCKBLKCYP2C9 | |
| SCHEMBL3934779 | 0.82 | BRAF (0.77) | BRAFBTKLCKBLKCYP2C9 | |
| SCHEMBL3934251 | 0.80 | BRAF (0.64) | BRAFBTKLCKBLKCYP2C9 | |
| SCHEMBL3936045 | 0.79 | BRAF (0.62) | BRAFBTKBLKCYP2C9 | |
| SCHEMBL3934757 | 0.79 | BRAF (0.62) | BRAFBTKLCKCYP2C9MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831198-B1 | PYRIDINE CARBOXAMIDE DERIVATIVES FOR USE AS ANTICANCER AGENTS | ASTRAZENECA AB (SE) | 2009-04-08 | — | — | EP | disclosed |
| CN-101128454-A | Pyridine carboxamide derivatives for use as anticancer agents | ASTRAZENECA AB (SE) | 2008-02-20 | — | — | CN | disclosed |