Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 6/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 4/20 | 0.32 |
| ▸ | TLR9 | Q9NR96 | 3/20 | 0.32 |
| ▸ | TLR4 | O00206 | 2/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | DRD4 | P21917 | 1/20 | 0.31 |
| ▸ | DRD3 | P35462 | 1/20 | 0.31 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13961185 | 0.66 | TLR8 (0.36) | TLR8TLR7TLR9TLR4DRD2 | |
| SCHEMBL2428960 | 0.66 | GRM2 (0.38) | TLR8TLR7TLR9TLR4DRD2 | |
| SCHEMBL24447954 | 0.59 | PDE4D (0.36) | TLR8TLR7TLR9TLR4IRAK4 | |
| SCHEMBL1407155 | 0.59 | BAZ2B (0.43) | — | |
| SCHEMBL25341920 | 0.59 | MAPT (0.39) | IRAK4 | |
| SCHEMBL25113904 | 0.58 | PDE4D (0.43) | TLR8TLR7TLR9TLR4IRAK4 | |
| SCHEMBL26762008 | 0.57 | TLR8 (0.42) | TLR8TLR7TLR9TLR4 | |
| SCHEMBL26352388 | 0.56 | PDE4D (0.39) | TLR8TLR7TLR9TLR4 | |
| SCHEMBL1407057 | 0.56 | BAZ2B (0.39) | — | |
| SCHEMBL24345435 | 0.56 | PDE4D (0.43) | TLR8TLR7TLR9TLR4IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009009411-A1 | SUBSTITUTED HETEROCYCLIC ETHERS AND THEIR USE IN CNS DISORDERS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-01-15 | — | — | WO | disclosed |