Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | FAAH | O00519 | 2/20 | 0.44 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.43 |
| ▸ | NAMPT | P43490 | 4/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL779385 | 0.88 | NAMPT (0.43) | SMN1; SMN2CHRNA7NAMPTKCNH2MAPT | |
| SCHEMBL3933614 | 0.82 | CHRNA7 (0.54) | SMN1; SMN2CHRNA7NAMPTKCNH2GRIN2B | |
| SCHEMBL780140 | 0.82 | CHRNA7 (0.61) | CHRNA7KCNH2 | |
| Hydrochloric Acid SCHEMBL779438 | 0.81 | KCNH2 (0.61) | CHRNA7KCNH2 | |
| SCHEMBL3932432 | 0.76 | CHRNA7 (0.54) | FAAHCHRNA7KCNH2MAPTRAB9A | |
| SCHEMBL3929838 | 0.74 | CHRNA7 (0.67) | CHRNA7KCNH2 | |
| SCHEMBL15841980 | 0.74 | CHRNA7 (0.58) | CHRNA7KCNH2 | |
| SCHEMBL778271 | 0.73 | CHRNA7 (0.74) | CHRNA7KCNH2 | |
| SCHEMBL3939516 | 0.73 | CHRNA7 (0.59) | CHRNA7KCNH2 | |
| SCHEMBL779797 | 0.72 | CHRNA7 (0.58) | CHRNA7KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044038-A2 | NOVEL PIPERAZINES, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE THEREOF | Cornerstone Therapeutics Inc. (US) | 2009-04-08 | — | — | EP | disclosed |
| WO-2007146066-A2 | NOVEL PIPERAZINES, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE THEREOF | CRITICAL THERAPEUTICS, INC. (US) | 2007-12-21 | — | — | WO | disclosed |