Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 2/20 | 0.61 |
| ▸ | KDR | P35968 | 1/20 | 0.61 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.61 |
| ▸ | CSF1R | P07333 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | RECQL | P46063 | 1/20 | 0.57 |
| ▸ | NR2E1 | Q9Y466 | 4/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | BRAF | P15056 | 5/20 | 0.55 |
| ▸ | ABL1 | P00519 | 4/20 | 0.55 |
| ▸ | BCR | P11274 | 3/20 | 0.55 |
| ▸ | EGFR | P00533 | 1/20 | 0.55 |
| ▸ | LCK | P06239 | 1/20 | 0.55 |
| ▸ | FYN | P06241 | 1/20 | 0.55 |
| ▸ | YES1 | P07947 | 1/20 | 0.55 |
| ▸ | LYN | P07948 | 1/20 | 0.55 |
| ▸ | HCK | P08631 | 1/20 | 0.55 |
| ▸ | SRC | P12931 | 1/20 | 0.55 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4252903 | 0.84 | CSF1R (0.66) | KITCSF1RKDM4EPOLBRECQL | |
| SCHEMBL3720917 | 0.84 | CSF1R (0.65) | KITCSF1RKDM4EPOLBRECQL | |
| SCHEMBL15381989 | 0.83 | CSF1R (0.71) | KITCSF1RKDM4EPOLBRECQL | |
| SCHEMBL4252904 | 0.81 | CSF1R (0.68) | KITCSF1RKDM4EPOLBRECQL | |
| SCHEMBL21612152 | 0.81 | CSF1R (0.71) | KITCSF1RKDM4EPOLBRECQL | |
| SCHEMBL3715032 | 0.79 | CSF1R (0.66) | KITCSF1RKDM4EPOLBRECQL | |
| SCHEMBL15381988 | 0.79 | CSF1R (0.66) | KITCSF1RKDM4EPOLBRECQL | |
| SCHEMBL19376837 | 0.78 | CSF1R (0.74) | KITCSF1RKDM4EPOLBRECQL | |
| SCHEMBL17103383 | 0.78 | CSF1R (0.64) | KITCSF1RKDM4EPOLBRECQL | |
| SCHEMBL1420281 | 0.78 | NR2E1 (0.74) | KITCSF1RKDM4EPOLBRECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831198-B1 | PYRIDINE CARBOXAMIDE DERIVATIVES FOR USE AS ANTICANCER AGENTS | ASTRAZENECA AB (SE) | 2009-04-08 | — | — | EP | disclosed |