Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 14/20 | 0.83 |
| ▸ | CSF1R | P07333 | 6/20 | 0.69 |
| ▸ | KIT | P10721 | 1/20 | 0.64 |
| ▸ | KDR | P35968 | 1/20 | 0.64 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.64 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.57 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3931806 | 0.94 | BRAF (0.78) | BRAFCSF1RKITKDRMAPK14 | |
| SCHEMBL1276331 | 0.92 | BRAF (0.76) | BRAFCSF1RKITKDRMAPK14 | |
| SCHEMBL3942520 | 0.91 | BRAF (1.00) | BRAFCSF1RKITKDRMAPK14 | |
| SCHEMBL1276797 | 0.91 | BRAF (0.78) | BRAFCSF1RKITKDRMAPK14 | |
| SCHEMBL1276598 | 0.89 | BRAF (0.70) | BRAFCSF1RKITKDRMAPK14 | |
| SCHEMBL3931994 | 0.88 | CSF1R (0.65) | BRAFCSF1RCYP11B1CYP11B2 | |
| SCHEMBL3941714 | 0.88 | BRAF (0.83) | BRAFCSF1RKITKDRMAPK14 | |
| SCHEMBL3938338 | 0.86 | BRAF (0.77) | BRAFCSF1RKITKDRMAPK14 | |
| SCHEMBL3941877 | 0.86 | BRAF (0.83) | BRAFCSF1RCYP11B2 | |
| SCHEMBL3934404 | 0.86 | CSF1R (0.83) | BRAFCSF1RCYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831198-B1 | PYRIDINE CARBOXAMIDE DERIVATIVES FOR USE AS ANTICANCER AGENTS | ASTRAZENECA AB (SE) | 2009-04-08 | — | — | EP | disclosed |