Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 3/20 | 0.52 |
| ▸ | PIK3CA | P42336 | 13/20 | 0.49 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.49 |
| ▸ | MTOR | P42345 | 14/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 8/20 | 0.45 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3927778 | 0.93 | PIK3CA (0.49) | ATRPIK3CAPIK3CDMTORPIK3CG | |
| SCHEMBL3937475 | 0.93 | PIK3CA (0.54) | ATRPIK3CAPIK3CDMTORPIK3CG | |
| SCHEMBL3936867 | 0.91 | ATR (0.55) | ATRPIK3CAPIK3CDMTORPIK3CG | |
| SCHEMBL3936000 | 0.89 | ATR (0.54) | ATRPIK3CAPIK3CDMTORPIK3CG | |
| SCHEMBL3937382 | 0.89 | ATR (0.60) | ATRPIK3CAPIK3CDMTORPIK3CG | |
| SCHEMBL3936300 | 0.89 | MTOR (0.57) | PIK3CAPIK3CDMTORPIK3CGPIK3CB | |
| SCHEMBL3930221 | 0.88 | PIK3CA (0.63) | ATRPIK3CAPIK3CDMTORPIK3CG | |
| SCHEMBL3926919 | 0.86 | MTOR (0.56) | PIK3CAPIK3CDMTORPIK3CGPIK3CB | |
| SCHEMBL3934720 | 0.86 | MTOR (0.56) | PIK3CAPIK3CDMTORPIK3CGPIK3CB | |
| SCHEMBL3936054 | 0.86 | ATR (0.61) | ATRPIK3CAPIK3CDMTORPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101801962-A | Trisubstituted pyrimidine derivatives for the treatment of proliferative diseases | ASTRAZENECA AB | 2010-08-11 | — | — | CN | disclosed |
| EP-2074118-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | AstraZeneca AB (SE) | 2009-07-01 | — | — | EP | disclosed |
| US-20090018134-A1 | Compounds - 945 | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | US | disclosed |
| US-20090018134-A1 | Compounds - 945 | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | US | disclosed |
| US-20090018134-A1 | Compounds - 945 | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | US | disclosed |
| WO-2009007748-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090018134-A1 | Compounds - 945 | MTOR, PIK3CA, PIK3R5 | ATR 1185/4885PIK3CA 2/4885PIK3CD 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.