Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 6/20 | 0.45 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | PTGES | O14684 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3937119 | 0.90 | GRM5 (0.47) | GRM5FFAR1PTPN1PTGESALDH1A1 | |
| SCHEMBL2951986 | 0.84 | FFAR1 (0.47) | GRM5FFAR1PTPN1KCNH2PTGES | |
| SCHEMBL4174001 | 0.83 | GRM5 (0.49) | GRM5FFAR1PTPN1PTGES | |
| SCHEMBL2946792 | 0.83 | HTR2C (0.48) | GRM5FFAR1PTPN1KCNH2PTGES | |
| SCHEMBL5092655 | 0.81 | GRM5 (0.40) | GRM5FFAR1HDAC3HDAC1HDAC2 | |
| SCHEMBL5092664 | 0.81 | GRM5 (0.40) | GRM5FFAR1HDAC3HDAC1HDAC2 | |
| SCHEMBL2950490 | 0.81 | FFAR1 (0.49) | GRM5FFAR1PTPN1PTGES | |
| SCHEMBL2236377 | 0.81 | FFAR1 (0.53) | GRM5FFAR1HDAC1PTPN1PTGES | |
| SCHEMBL3940735 | 0.80 | FFAR1 (0.43) | FFAR1KCNH2 | |
| SCHEMBL7517707 | 0.80 | FFAR1 (0.62) | FFAR1PTPN1PTGES |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2046746-A2 | CHEMICAL COMPOUNDS | Praecis Pharmaceuticals Incorporated (US) | 2009-04-15 | — | — | EP | disclosed |
| WO-2008016692-A2 | CHEMICAL COMPOUNDS | PRAECIS PHARMACEUTICALS INCORPORATED (US) | 2008-02-07 | — | — | WO | disclosed |