Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 1/20 | 0.41 |
| ▸ | CCR5 | P51681 | 1/20 | 0.41 |
| ▸ | CCR8 | P51685 | 1/20 | 0.41 |
| ▸ | NOS3 | P29474 | 2/20 | 0.39 |
| ▸ | NOS1 | P29475 | 2/20 | 0.39 |
| ▸ | NOS2 | P35228 | 2/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.38 |
| ▸ | PLAU | P00749 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.35 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.34 |
| ▸ | PROKR1 | Q8TCW9 | 2/20 | 0.34 |
| ▸ | TTK | P33981 | 1/20 | 0.34 |
| ▸ | RIOK2 | Q9BVS4 | 2/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL828662 | 0.82 | NPC1 (0.42) | CCR1CCR5CCR8NOS3NOS1 | |
| SCHEMBL29650144 | 0.81 | CNR2 (0.42) | USP30LMNAAAK1PAX8SSTR4 | |
| SCHEMBL3928632 | 0.81 | CNR2 (0.42) | USP30LMNAAAK1PAX8SSTR4 | |
| SCHEMBL29580743 | 0.81 | SSTR4 (0.40) | USP30KDM4EAAK1PAX8SSTR4 | |
| SCHEMBL29417518 | 0.81 | USP30 (0.39) | USP30AAK1PAX8SSTR4TTK | |
| SCHEMBL25295526 | 0.81 | SSTR4 (0.40) | USP30AAK1PAX8SSTR4TTK | |
| SCHEMBL12678539 | 0.81 | SSTR4 (0.40) | USP30KDM4EAAK1PAX8SSTR4 | |
| SCHEMBL16989275 | 0.81 | KDM4E (0.47) | USP30KDM4EMAPK1DYRK1A | |
| SCHEMBL13588405 | 0.80 | USP30 (0.38) | USP30AAK1PAX8SSTR4PROKR1 | |
| SCHEMBL15070166 | 0.79 | AAK1 (0.39) | USP30LMNAKDM4EMAPK1AAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1918127-B | New cyclocompound having 4-pyridylalkylthio group to which substituted or unsubstituted amino group is introduced | SANTEN PHARMACEUTICAL CO.,LTD. (JP) | 2012-02-15 | — | — | CN | disclosed |
| US-20090054428-A1 | NOVEL PYRIMIDINE DERIVATIVES 965 | ASTRAZENECA AB (SE) | 2009-02-26 | — | — | US | disclosed |
| WO-2009010794-A1 | 2,4-DIAMINO-PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2009-01-22 | — | — | WO | disclosed |
| CN-1918127-A | New cyclocompound having 4-pyridylalkylthio group to which sustituted or unsubstituted amino group is introduced | SANTEN PHARMACEUTICAL CO LTD (JP) | 2007-02-21 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090054428-A1 | NOVEL PYRIMIDINE DERIVATIVES 965 | EPHB4, EPHB1, EPHB3 | CCR1 2126/4885CCR5 1063/4885CCR8 3080/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.