Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 6/20 | 0.33 |
| ▸ | ATR | Q13535 | 2/20 | 0.33 |
| ▸ | FLT3 | P36888 | 4/20 | 0.33 |
| ▸ | CXCR3 | P49682 | 2/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.32 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.32 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.32 |
| ▸ | ITK | Q08881 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3928879 | 0.84 | ATR (0.40) | ATRFLT3FGFR1FGFR2FGFR3 | |
| SCHEMBL3927246 | 0.84 | FGFR1 (0.36) | ATRFLT3FGFR1FGFR2FGFR3 | |
| SCHEMBL14311507 | 0.82 | FGFR1 (0.35) | ATRFLT3FGFR1FGFR2FGFR3 | |
| SCHEMBL3924589 | 0.82 | FGFR1 (0.38) | ATRFLT3FGFR1FGFR2FGFR3 | |
| SCHEMBL3924807 | 0.82 | ATR (0.34) | ATRFLT3FGFR1FGFR2FGFR3 | |
| SCHEMBL4125135 | 0.81 | MAPT (0.42) | FGFR1FGFR2FGFR3KDR | |
| SCHEMBL4136031 | 0.81 | ITK (0.36) | ATRFLT3FGFR1FGFR2FGFR3 | |
| SCHEMBL3928295 | 0.80 | ITK (0.37) | ATRFLT3FGFR1FGFR2FGFR3 | |
| SCHEMBL3935076 | 0.78 | ITK (0.37) | FLT3FGFR1FGFR2FGFR3KDR | |
| SCHEMBL3933717 | 0.78 | ITK (0.38) | FLT3FGFR1FGFR2FGFR3KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2041119-A1 | PYRAZOLYLBENZIMIDAZOLE DERIVATIVES, COMPOSITIONS CONTAINING THEM AND USE THEREOF | Aventis Pharma S.A. (FR) | 2009-04-01 | — | — | EP | disclosed |
| WO-2008003857-A1 | PYRAZOLYLBENZIMIDAZOLE DERIVATIVES, COMPOSITIONS CONTAINING THEM AND USE THEREOF | AVENTIS PHARMA S.A. (FR) | 2008-01-10 | — | — | WO | disclosed |