Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | HPGD | P15428 | 5/20 | 0.34 |
| ▸ | PKM | P14618 | 4/20 | 0.34 |
| ▸ | GLA | P06280 | 4/20 | 0.34 |
| ▸ | GAA | P10253 | 4/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 3/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | CASP1 | P29466 | 1/20 | 0.30 |
| ▸ | CASP7 | P55210 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3934662 | 0.91 | KDM4E (0.32) | KDM4EALDH1A1HPGDPKMGLA | |
| SCHEMBL13843277 | 0.86 | JAK2 (0.36) | KDM4EALDH1A1HPGDPKMGLA | |
| SCHEMBL3943935 | 0.86 | KDM4E (0.36) | KDM4EALDH1A1HPGDPKMGLA | |
| SCHEMBL3939618 | 0.84 | HTT (0.34) | KDM4EALDH1A1HPGDPKMGLA | |
| SCHEMBL13843280 | 0.84 | KDM4E (0.34) | KDM4EALDH1A1HPGDPKMGLA | |
| SCHEMBL3941696 | 0.83 | HTT (0.39) | KDM4EALDH1A1HPGDPKMGLA | |
| SCHEMBL3937495 | 0.83 | HTT (0.33) | KDM4EALDH1A1HPGDPKMGLA | |
| SCHEMBL13843319 | 0.81 | HTT (0.39) | KDM4EALDH1A1HTTBRD4HSD17B10 | |
| SCHEMBL3936654 | 0.81 | HTT (0.32) | KDM4EALDH1A1HPGDPKMGLA | |
| SCHEMBL3935328 | 0.81 | HTT (0.32) | KDM4EALDH1A1HPGDPKMGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7528140-B2 | Substituted pyrrolo[3,2-d]pyrimidines as glycogen synthase kinase (GSK) inhibitors | TEIJIN LIMITED (JP) | 2009-05-05 | — | — | US | disclosed |
| US-7528140-B2 | Substituted pyrrolo[3,2-d]pyrimidines as glycogen synthase kinase (GSK) inhibitors | TEIJIN LIMITED (JP) | 2009-05-05 | — | — | US | disclosed |
| CN-1633436-A | Pyrrolopyrimidine derivatives | TEIJIN LTD (JP) | 2005-06-29 | — | — | CN | disclosed |
| EP-1477489-A1 | PYRROLOPYRIMIDINE DERIVATIVES | TEIJIN LIMITED (JP) | 2004-11-17 | — | — | EP | disclosed |