Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 14/20 | 0.36 |
| ▸ | HTR2C | P28335 | 14/20 | 0.36 |
| ▸ | HTR2B | P41595 | 14/20 | 0.36 |
| ▸ | AKT1 | P31749 | 1/20 | 0.36 |
| ▸ | AKT2 | P31751 | 1/20 | 0.36 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 2/20 | 0.35 |
| ▸ | JAK3 | P52333 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL2262415 | 0.99 | HTR2A (0.36) | HTR2AHTR2CHTR2BAKT1AKT2 | |
| Hydrochloric Acid SCHEMBL2262423 | 0.99 | HTR2A (0.36) | HTR2AHTR2CHTR2BAKT1AKT2 | |
| SCHEMBL22533475 | 0.81 | AKT1 (0.44) | HTR2CAKT1AKT2AKT3 | |
| SCHEMBL3944642 | 0.81 | AKT1 (0.44) | HTR2CAKT1AKT2AKT3 | |
| Hydrochloric Acid SCHEMBL2262653 | 0.80 | AKT1 (0.44) | HTR2CAKT1AKT2AKT3 | |
| Hydrochloric Acid SCHEMBL2262657 | 0.80 | AKT1 (0.44) | HTR2CAKT1AKT2AKT3 | |
| SCHEMBL2577724 | 0.78 | AKT1 (0.38) | HTR2AHTR2CHTR2BAKT1GSK3B | |
| SCHEMBL2577720 | 0.78 | AKT1 (0.38) | HTR2AHTR2CHTR2BAKT1GSK3B | |
| Hydrochloric Acid SCHEMBL2577999 | 0.77 | AKT1 (0.38) | HTR2AHTR2CHTR2BAKT1GSK3B | |
| Hydrochloric Acid SCHEMBL1298981 | 0.77 | AKT1 (0.38) | HTR2AHTR2CHTR2BAKT1GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049500-A1 | CYCLOPENTA [D] PYRIMIDINES AS AKT PROTEIN KINASE INHIBITORS | Array Biopharma, Inc. (US) | 2009-04-22 | — | — | EP | disclosed |
| WO-2008006032-A1 | CYCLOPENTA [D] PYRIMIDINES AS AKT PROTEIN KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2008-01-10 | — | — | WO | disclosed |