Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 12/20 | 0.75 |
| ▸ | MAPK13 | O15264 | 12/20 | 0.75 |
| ▸ | MAPK12 | P53778 | 11/20 | 0.75 |
| ▸ | MAPK11 | Q15759 | 11/20 | 0.75 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.65 |
| ▸ | CDK8 | P49336 | 1/20 | 0.65 |
| ▸ | JAK2 | O60674 | 1/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1012719 | 0.88 | MAPK13 (0.78) | MAPK14MAPK13MAPK12MAPK11CDK8 | |
| SCHEMBL1600309 | 0.88 | CDK8 (0.82) | MAPK14MAPK13MAPK12MAPK11PTK2 | |
| SCHEMBL1012359 | 0.85 | CDK8 (0.57) | MAPK14MAPK13MAPK12MAPK11CDK8 | |
| SCHEMBL3621438 | 0.84 | CDK8 (0.67) | MAPK14MAPK13MAPK12MAPK11PTK2 | |
| SCHEMBL27217836 | 0.84 | MAPK14 (0.72) | MAPK14MAPK13MAPK12MAPK11CDK8 | |
| SCHEMBL1013422 | 0.84 | MAPK13 (0.69) | MAPK14MAPK13MAPK12MAPK11JAK2 | |
| SCHEMBL15485142 | 0.82 | MAPK14 (0.77) | MAPK14MAPK13MAPK12MAPK11PTK2 | |
| SCHEMBL16054415 | 0.82 | CDK8 (0.64) | MAPK14MAPK13MAPK12MAPK11PTK2 | |
| SCHEMBL1015661 | 0.81 | MAPK14 (0.60) | MAPK14MAPK13MAPK12MAPK11PTK2 | |
| SCHEMBL4226618 | 0.81 | CDK8 (0.63) | MAPK14MAPK13MAPK12MAPK11PTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044053-A2 | UREA COMPOUNDS USEFUL IN THE TREATMENT OF CANCER | Bayer Healthcare, LLC (US) | 2009-04-08 | — | — | EP | disclosed |
| WO-2007064872-A2 | UREA COMPOUNDS USEFUL IN THE TREATMENT OF CANCER | BAYER HEALTHCARE LLC (US) | 2007-06-07 | — | — | WO | disclosed |