Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 9/20 | 0.75 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.75 |
| ▸ | KIT | P10721 | 3/20 | 0.75 |
| ▸ | SRC | P12931 | 2/20 | 0.75 |
| ▸ | ABL1 | P00519 | 1/20 | 0.75 |
| ▸ | BRAF | P15056 | 5/20 | 0.72 |
| ▸ | CSF1R | P07333 | 3/20 | 0.72 |
| ▸ | BTK | Q06187 | 11/20 | 0.67 |
| ▸ | KDR | P35968 | 3/20 | 0.67 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.64 |
| ▸ | EGFR | P00533 | 1/20 | 0.61 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.61 |
| ▸ | TEC | P42680 | 1/20 | 0.61 |
| ▸ | TXK | P42681 | 1/20 | 0.61 |
| ▸ | BLK | P51451 | 1/20 | 0.61 |
| ▸ | BMX | P51813 | 1/20 | 0.61 |
| ▸ | JAK3 | P52333 | 1/20 | 0.61 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3934754 | 0.89 | LCK (0.79) | LCKMAPK14KITSRCABL1 | |
| SCHEMBL3943066 | 0.89 | LCK (0.79) | LCKMAPK14KITSRCABL1 | |
| SCHEMBL27699869 | 0.88 | LCK (0.81) | LCKMAPK14KITSRCABL1 | |
| SCHEMBL3933392 | 0.87 | LCK (0.79) | LCKMAPK14KITSRCABL1 | |
| SCHEMBL3935008 | 0.86 | LCK (0.78) | LCKMAPK14KITSRCABL1 | |
| SCHEMBL3935176 | 0.86 | LCK (0.78) | LCKMAPK14KITSRCABL1 | |
| SCHEMBL27720421 | 0.86 | LCK (0.78) | LCKMAPK14KITSRCABL1 | |
| SCHEMBL2947918 | 0.86 | LCK (1.00) | LCKMAPK14KITSRCABL1 | |
| SCHEMBL3932672 | 0.86 | LCK (0.74) | LCKMAPK14KITSRCABL1 | |
| SCHEMBL3935655 | 0.85 | BRAF (0.77) | LCKMAPK14KITSRCABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831198-B1 | PYRIDINE CARBOXAMIDE DERIVATIVES FOR USE AS ANTICANCER AGENTS | ASTRAZENECA AB (SE) | 2009-04-08 | — | — | EP | disclosed |
| EP-1831198-A1 | PYRIDINE CARBOXAMIDE DERIVATIVES FOR USE AS ANTICANCER AGENTS | AstraZeneca AB (SE) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006067446-A1 | PYRIDINE CARBOXAMIDE DERIVATIVES FOR USE AS ANTICANCER AGENTS | ASTRAZENECA AB (SE) | 2006-06-29 | — | — | WO | disclosed |