Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 19/20 | 0.71 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.56 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | BTK | Q06187 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3940175 | 0.85 | BRAF (0.69) | BRAFCYP2C9 | |
| SCHEMBL3939889 | 0.83 | BRAF (1.00) | BRAFCYP2C9LCKBTK | |
| SCHEMBL3938207 | 0.75 | BRAF (0.72) | BRAFCYP2C9LCKBTK | |
| SCHEMBL3934779 | 0.75 | BRAF (0.77) | BRAFCYP2C9LCKBTK | |
| SCHEMBL4167730 | 0.75 | BRAF (0.84) | BRAFCYP2C9LCK | |
| SCHEMBL4788091 | 0.74 | BRAF (0.51) | BRAF | |
| SCHEMBL3934034 | 0.74 | BRAF (0.83) | BRAFCYP2C9LCKBTK | |
| SCHEMBL4175332 | 0.74 | BRAF (0.67) | BRAFCYP2C9LCKBTK | |
| SCHEMBL3934373 | 0.74 | BRAF (0.71) | BRAFCYP2C9LCKBTK | |
| SCHEMBL3934259 | 0.74 | BRAF (0.82) | BRAFCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831198-B1 | PYRIDINE CARBOXAMIDE DERIVATIVES FOR USE AS ANTICANCER AGENTS | ASTRAZENECA AB (SE) | 2009-04-08 | — | — | EP | disclosed |